Effect of Different Feeding Method on Gastrointestinal Function of Critical Patients

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The intestine is the most vulnerable target organ in septic patients and is the first to be damaged organ in multiple organ dysfunction syndrome(MODS).Therefore, improving intestinal motility and mucosal barrier function is critical to the treatment of sepsis. Many studies have shown that, early enteral nutrition(EN) in patients with sepsis helps prevent and treat intestinal dysfunction, reducing ICU mortality and length of stay in ICU. However, there is little research on feeding methods. In this study the investigators will compare the outcomes of different feeding methods: continuously-pumped in 24 hours, continuouslypumped in 16 hours and intermittently-pumped through the stomach tube. The aim of this study is to investigate the effects of different feeding methods on intestinal function in septic patients.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: f
View:

• Septic patients in Department of Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine;

• APACHE-Ⅱ score greater than 15 points;

• Signing the informed consent.

Locations
Other Locations
China
2nd Affiliated Hospital of Guangzhou University of Chinese Medicine
RECRUITING
Guangzhou
Contact Information
Primary
Guang Yang
yangguang@gzucm.edu.cn
86-20-39318526
Time Frame
Start Date: 2020-07-01
Estimated Completion Date: 2025-06-30
Participants
Target number of participants: 90
Treatments
Active_comparator: 24-hours group
The critical patients randomized to 24-hours group will be received enteral nutrition preparation by 24 hours of continuously pumping through stomach tube every day.~Feeding will be started within 24 hours in admission of ICU. The time of therapy is 5 days.
Experimental: 16-hours group
The critical patients randomized to 16-hours group will be received enteral nutrition preparation by 16 hours of continuously pumping through stomach tube every day.~Feeding will be started within 24 hours in admission of ICU. The time of therapy is 5 days.
Experimental: intermittent group
The critical patients randomized to intermittent group will be received enteral nutrition preparations by four meals every day(08:00,12:00 18:00,22:00), each meal are pumped within 60min or 120min through stomach tube.Feeding will be started within 24 hours in admission of ICU. The time of therapy is 5 days
Related Therapeutic Areas
Sponsors
Leads: Guangdong Provincial Hospital of Traditional Chinese Medicine

This content was sourced from clinicaltrials.gov