Learn About Sepsis

What is the definition of Sepsis?

Sepsis is an illness in which the body has a severe, inflammatory response to bacteria or other germs.

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What are the alternative names for Sepsis?

Septicemia; Sepsis syndrome; Systemic inflammatory response syndrome; SIRS; Septic shock

What are the causes of Sepsis?

The symptoms of sepsis are not caused by the germs themselves. Instead, chemicals the body releases cause the response.

A bacterial infection anywhere in the body may set off the response that leads to sepsis. Common places where an infection might start include the:

  • Bloodstream
  • Bones (common in children)
  • Bowel (usually seen with peritonitis)
  • Kidneys (upper urinary tract infection, pyelonephritis or urosepsis)
  • Lining of the brain (meningitis)
  • Liver or gallbladder
  • Lungs (bacterial pneumonia)
  • Skin (cellulitis)

For people in the hospital, common sites of infection include intravenous lines, surgical wounds, surgical drains, and sites of skin breakdown, known as bedsores or pressure ulcers.

Sepsis commonly affects infants or older adults.

What are the symptoms of Sepsis?

In sepsis, blood pressure drops, resulting in shock. Major organs and body systems, including the kidneys, liver, lungs, and central nervous system may stop working properly because of poor blood flow.

A change in mental status and very fast breathing may be the earliest signs of sepsis.

In general, symptoms of sepsis can include:

  • Chills
  • Confusion or delirium
  • Fever or low body temperature (hypothermia)
  • Lightheadedness due to low blood pressure
  • Rapid heartbeat
  • Skin rash or mottled skin
  • Warm skin
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What are the current treatments for Sepsis?

A person with sepsis will be admitted to a hospital, usually in the intensive care unit (ICU). Antibiotics are usually given through a vein (intravenously).

Other medical treatments include:

  • Oxygen to help with breathing
  • Fluids given through a vein
  • Medicines that increase blood pressure
  • Dialysis if there is kidney failure
  • A breathing machine (mechanical ventilation) if there is lung failure
Who are the top Sepsis Local Doctors?
Highly rated in

National And Kapodistrian University Of Athens

2nd Department Of Critical Care Medicine 
Athens, ESYE31, GR 12462

Evangelos Bourboulis-Giamarellos is in Athens, Greece. Bourboulis-Giamarellos is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are Sepsis, Pneumonia, Necrosis, and Hidradenitis Suppurativa.

Highly rated in

Center For Sepsis Control And Care

Berlin, BE, DE 

Konrad Reinhart is in Berlin, Germany. Reinhart is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 4 other conditions, according to our data. His top areas of expertise are Sepsis, Toxic Shock Syndrome, Neonatal Sepsis, and Acute Kidney Failure.

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Highly rated in
Infectious Disease

Hot Topics In Infectious Disease

Udine, IT 

Matteo Bassetti is an Infectious Disease expert in Udine, Italy. Bassetti is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 16 other conditions, according to our data. His top areas of expertise are Sepsis, Pneumonia, Hospital-Acquired Pneumonia, and Pseudomonas Stutzeri Infections.

What is the outlook (prognosis) for Sepsis?

Sepsis is often life threatening, especially in people with a weak immune system or a long-term (chronic) illness.

Damage caused by a decrease in blood flow to vital organs such as the brain, heart, and kidneys may take time to improve. There may be long-term problems with these organs.

How do I prevent Sepsis?

The risk of sepsis can be reduced by getting all recommended vaccines.

In the hospital, careful hand washing can help prevent hospital-acquired infections that lead to sepsis. Prompt removal of urinary catheters and IV lines when they are no longer needed can also help prevent infections that lead to sepsis.

Intensive care unit (ICU)
What are the latest Sepsis Clinical Trials?
Prognostic Accuracy of qSOFA Score, SIRS Criteria, and EWS for In-hospital Mortality Among Adult Patients Presenting With Suspected Infection to the Emergency Department (PASSEM): a Multicentre Prospective Cohort Study
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Anakinra in Cerebral Haemorrhage to Target Secondary Injury Resulting From Neuroinflammation - a Phase II Clinical Trial
What are the Latest Advances for Sepsis?
Posterior scleral perforation due to endogenous endophthalmitis in a pregnant with selective IgA deficiency.
Septic shock induced by latent odontogenic orbital infection: a case report.
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Outcomes of Coronary Artery Disease Patients with Severe Left Ventricular Dysfunction Undergoing Surgical Management.
Who are the sources who wrote this article ?

Published Date : October 25, 2020
Published By : Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School; Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Shapiro NI, Jones AE. Sepsis syndromes. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 130.

Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-810. PMID 26903338 pubmed.ncbi.nlm.nih.gov/26903338/.

van der Poll T, Wiersinga WJ. Sepsis and septic shock. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 73.