Sepsis is an illness in which the body has a severe, inflammatory response to bacteria or other germs.
Septicemia; Sepsis syndrome; Systemic inflammatory response syndrome; SIRS; Septic shock
The symptoms of sepsis are not caused by the germs themselves. Instead, chemicals the body releases cause the response.
A bacterial infection anywhere in the body may set off the response that leads to sepsis. Common places where an infection might start include the:
For people in or recently discharged from the hospital, common sites of infection include intravenous lines, surgical wounds, surgical drains, and sites of skin breakdown, known as bedsores or pressure ulcers.
Sepsis commonly affects infants or older adults.
In sepsis, blood pressure drops, resulting in shock. Major organs and body systems, including the kidneys, liver, lungs, and central nervous system may stop working properly because of poor blood flow.
A change in mental status and very fast breathing may be the earliest signs of sepsis.
In general, symptoms of sepsis can include:
A person with sepsis will be admitted to a hospital, usually in the intensive care unit (ICU). Antibiotics are usually given through a vein (intravenously).
Other medical treatments include:
Peter Pickkers practices in Nijmegen, Netherlands. Pickkers is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 16 other conditions, according to our data. His top areas of expertise are Sepsis, Delirium, COVID-19, Coronary Artery Bypass Graft (CABG), and Heart Bypass Surgery.
Evangelos Bourboulis-Giamarellos practices in Athens, Greece. Bourboulis-Giamarellos is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 22 other conditions, according to our data. His top areas of expertise are Sepsis, Small Bowel Bacterial Overgrowth, Pneumonia, Small Bowel Resection, and Endoscopy.
Tom Van Der Poll practices in Amsterdam, Netherlands. Van Der Poll is rated as an Elite expert by MediFind in the treatment of Sepsis. He is also highly rated in 26 other conditions, according to our data. His top areas of expertise are Sepsis, Pneumonia, Melioidosis, Strep Throat, and Bone Marrow Transplant.
Sepsis is often life threatening, especially in people with a weak immune system or a long-term (chronic) illness.
Damage caused by a decrease in blood flow to vital organs such as the brain, heart, and kidneys may take time to improve. There may be long-term problems with these organs.
The risk of sepsis can be reduced by getting all recommended vaccines.
In the hospital, careful hand washing can help prevent hospital-acquired infections that lead to sepsis. Prompt removal of urinary catheters and IV lines when they are no longer needed can also help prevent infections that lead to sepsis.
Summary: The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy. The main questions aims to answer are: • does application of vancomycine prior to ECMO liberation have an impact of bloodstream infections? Participants will get 1 dose of vancomycine I.V. (15-20 mg per kgKG...
Summary: This is a multicenter, open-label, non-comparator, single-arm study to evaluate the efficacy, safety, tolerability and PK (pharmacokinetics) of oral SCY-078 as an emergency use treatment for patients with a documented Candida auris infection.
Published Date: September 10, 2022
Published By: Jatin M. Vyas, MD, PhD, Associate Professor in Medicine, Harvard Medical School; Associate in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Shapiro NI, Jones AE. Sepsis syndrome. In: Walls RM, Hockberger RS, Gausche-Hill M, Erickson TB, Wilcox SR, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 127.
Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-810. PMID 26903338 pubmed.ncbi.nlm.nih.gov/26903338/.
van der Poll T, Wiersinga WJ. Sepsis and septic shock. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 73.