Condition 101 About Sepsis

What is the definition of Sepsis?

Sepsis is an illness in which the body has a severe, inflammatory response to bacteria or other germs.

What are the alternative names for Sepsis?

Septicemia; Sepsis syndrome; Systemic inflammatory response syndrome; SIRS; Septic shock

What are the causes for Sepsis?

The symptoms of sepsis are not caused by the germs themselves. Instead, chemicals the body releases cause the response.

A bacterial infection anywhere in the body may set off the response that leads to sepsis. Common places where an infection might start include the:

  • Bloodstream
  • Bones (common in children)
  • Bowel (usually seen with peritonitis)
  • Kidneys (upper urinary tract infection, pyelonephritis or urosepsis)
  • Lining of the brain (meningitis)
  • Liver or gallbladder
  • Lungs (bacterial pneumonia)
  • Skin (cellulitis)

For people in the hospital, common sites of infection include intravenous lines, surgical wounds, surgical drains, and sites of skin breakdown, known as bedsores or pressure ulcers.

Sepsis commonly affects infants or older adults.

What are the symptoms for Sepsis?

In sepsis, blood pressure drops, resulting in shock. Major organs and body systems, including the kidneys, liver, lungs, and central nervous system may stop working properly because of poor blood flow.

A change in mental status and very fast breathing may be the earliest signs of sepsis.

In general, symptoms of sepsis can include:

  • Chills
  • Confusion or delirium
  • Fever or low body temperature (hypothermia)
  • Lightheadedness due to low blood pressure
  • Rapid heartbeat
  • Skin rash or mottled skin
  • Warm skin

What are the current treatments for Sepsis?

A person with sepsis will be admitted to a hospital, usually in the intensive care unit (ICU). Antibiotics are usually given through a vein (intravenously).

Other medical treatments include:

  • Oxygen to help with breathing
  • Fluids given through a vein
  • Medicines that increase blood pressure
  • Dialysis if there is kidney failure
  • A breathing machine (mechanical ventilation) if there is lung failure

What is the outlook (prognosis) for Sepsis?

Sepsis is often life threatening, especially in people with a weak immune system or a long-term (chronic) illness.

Damage caused by a decrease in blood flow to vital organs such as the brain, heart, and kidneys may take time to improve. There may be long-term problems with these organs.

How do I prevent Sepsis?

The risk of sepsis can be reduced by getting all recommended vaccines.

In the hospital, careful hand washing can help prevent hospital-acquired infections that lead to sepsis. Prompt removal of urinary catheters and IV lines when they are no longer needed can also help prevent infections that lead to sepsis.


Munford RS, Suffredini AF. Sepsis, severe sepsis, and septic shock. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Updated Edition. 8th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 75.

Shapiro NI, Jones AE. Sepsis syndromes. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA: Elsevier; 2018:chap 130.

Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-810. PMID 26903338

Latest Advances On Sepsis

  • Condition: Sepsis
  • Journal: JAMA
  • Treatment Used: Vitamin C, Thiamine, and Hydrocortisone
  • Number of Patients: 501
  • Published —
In this study, researchers evaluated the outcomes of using a combination of vitamin C, thiamine, and corticosteroids for the treatment of sepsis.
  • Condition: Asian Patients with Natural Killer/T-Cell Lymphoma (NKTCL)
  • Journal: Journal of hematology & oncology
  • Treatment Used: Daratumumab Monotherapy
  • Number of Patients: 32
  • Published —
This study evaluated daratumumab monotherapy (treatment with a single drug) for patients with relapsed (worsening) or refractory (resistant to treatment; R/R) natural killer/T-cell lymphoma (unique type of non-Hodgkin lymphoma that is almost always associated with Epstein-Barr virus; NKTCL).

Clinical Trials For Sepsis

Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Diagnostic Test
  • Participants: 51645
  • Start Date: May 1, 2022
Gram Type Infection-Specific Sepsis Identification Using Machine Learning
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 2
  • Intervention Type: Drug
  • Participants: 153
  • Start Date: January 2022
Sevoflurane Sedation: A Potentially Promising Immunomodulation in Patients With Septic Shock