Effects of Fluid Resuscitation on Capillary Refilling Time and Organ Functions in Septic Shock
Since the ultimate target of resuscitation is the microcirculation, normal microcirculatory perfusion appears to be the primary target of ideal resuscitation in septic shock patients. In septic shock patients, microcirculation of the skin may be impaired in the early period due to early sympathetic nervous system activation. Assessment of skin perfusion has also become popular in shock resuscitation because it is easily accessible for clinical assessment. Studies in septic shock patients, showed that capillary refill time correlated with lactate levels measured at 6 hours of resuscitation and was associated with mortality. Additionally, early normalization of capillary refill time has been associated with improved survival in septic shock This study aimed to evaluate the relationship between the change in capillary filling time (microcirculation) and organ perfusion after fluid resuscitation in sepsis patients in intensive care.
• Over 18 years old
• Admitted to intensive care with a diagnosis of sepsis or septic shock
• Systolic blood pressure \< 90 mmHg or Mean blood pressure \< 65 mmHg
• Those who need vasopressor medication
• Urine output \< 0.5 ml/kg/h for at least two hours
• Tachycardia (Heart rate \> 100/min)
• Serum Lactate \> 2 mmol/L
• Patients with central venous oxygen saturation (ScvO) \< 70%