Clinical Application of Metagenomic Next-Generation Sequencing-Guided Anti-Infection Strategies in AIDS Patients With Severe Pneumonia and/or Sepsis
This study aims to observe the effectiveness of clinical application in guiding anti-infection treatments in AIDS patients with severe pneumonia and/or sepsis using Metagenomic Next-Generation Sequencing-based technology in the real world
• Confirmed HIV infection;
• Progression to AIDS stage: CD4+ count \<200 cells/ul and/or occurrence of AIDS opportunistic infections;
• Age between 18 and 65 years;
• Meeting the diagnosis of severe pneumonia or septic shock:
‣ The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia;
⁃ The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's Chinese Guidelines for the Emergency Treatment of Sepsis/Septic Shock (2018).