Mechanisms of Acute Kidney Injury in Severe Infections
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
⁃ Patients with sepsis and AKI
• \> 30 years
• At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination
⁃ Healthy volunteers
• \> 30 years
• No previously known kidney disease
• Normal plasma creatinine value