Mechanisms of Acute Kidney Injury in Severe Infections

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Observational
SUMMARY

Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Healthy Volunteers: t
View:

⁃ Patients with sepsis and AKI

• \> 30 years

• At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination

⁃ Healthy volunteers

• \> 30 years

• No previously known kidney disease

• Normal plasma creatinine value

Locations
Other Locations
Sweden
Uppsala university hospital
RECRUITING
Uppsala
Contact Information
Primary
Miklos Lipcsey, MD, PhD
miklos.lipcsey@uu.se
+46186110000
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 15
Treatments
Patients with sepsis and AKI
Healthy controls
Related Therapeutic Areas
Sponsors
Leads: Uppsala University Hospital

This content was sourced from clinicaltrials.gov