Prevalence of the Aortic to Radial Pressure Gradient in States of Shock

Status: Recruiting
Location: See all (5) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY

First described in cardiac surgery, the aortic to radial pressure gradient (ATRAP) is the cause of an underestimation of the aortic pressure with a measure assumed with a radial catheter, and he can concert 1 of 3rd patients. The risks factor well known are small height, previous hypertension, long and difficult surgery, radial artery diameter less than 1.8mm. The ATRAP definition is a pressure difference between radial and femoral (same of the aortic pressure) pressure of 25mmHg on the systolic pressure, or a pressure difference on the mean pressure of 10mmHg, both measures realised by arterial canulation, and with a duration superior than 5 minutes. If this gradient appears in pathophysiological specifics situations, there is a risk of inappropriate administration of vasopressors, with more hospitalisation days, more side effect of vasopressors like an augmentation of myocardial work. The ATRAP is documented in septic shock with a prevalence between 21% and 27%. The ATRAP can appear in shocks, moreover with doses of equivalent norepinephrine of 0.5 µg/kg/min who is use for the definition of refractive shock, the difference between the two pressure is higher if the dose of equivalent norepinephrine is higher than 1µg/kg/min. But the prevalence and risks factors are barely unknowns in this situation. Most of the time, a radial arterial catheter is used for hemodynamic monitoring for his simplicity of utilisation and the lows complications associated. Some medical teams in cardiac surgeries, or in intensive care unit (ICU) for the management of shocks used often radial and femoral arterial catheter. It seems there is no at risk for the utilisation of a radial and femoral arterial canulation. Out of the situation of cardiac surgery, there is a lack of information of the ATRAP, the objective of the study is to evaluate the prevalence of the ATRAP in shock, out of the situation of cardiac surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 99
Healthy Volunteers: f
View:

• age superior or equal 18 years

• Vasopressors support superior or equal 0.5 µg/kg/min of equivalent norepinephrine

• Invasive monitoring of blood pressure with a radial arterial catheter and a femoral arterial catheter decided by de physician

• Beginning of the shock less than 48 hours.

• Consent

Locations
Other Locations
France
Département d'anesthésie Réanimation Hôpital Cardiologique Louis Pradel/Groupement Hospitalier Est
RECRUITING
Bron
Centre hospitalier Lyon Sud/Groupement hospitalier Sud, Service d'anesthésie réanimation médecine intensive
RECRUITING
Lyon
Hôpital de la Croix-Rousse/Groupement hospitalier Nord, service d'anesthésie réanimation
RECRUITING
Lyon
Hôpital Edouard Heriot/ Groupement hospitalier Centre, service d'anesthésie réanimation
RECRUITING
Lyon
Hopital Edouard heriot/Groupement hospitalier Centre, service de médecine intensive réanimation
RECRUITING
Lyon
Contact Information
Primary
Matthias Jacquet-lagreze, Dr
matthias.jacquet-lagreze@chu-lyon.fr
0783426888
Backup
Martin Ruste, Dr
martin.ruste@chu-lyon.fr
0472118956
Time Frame
Start Date: 2024-10-03
Estimated Completion Date: 2026-11-03
Participants
Target number of participants: 180
Treatments
Intensive care unit patient with shock, who don't be in perioperative of cardiac surgery
Patients of age superior or equal of 18 years, with a vasopressor support superior 0.5 µg/kg/min of equivalent norepinephrine during more than 30 minutes.~The patients are not in perioperative of cardiac surgery (between the beginning of the intervention and 7 days after).~The patients have a monitoring of arterial pressure with a radial arterial catheter, and the physician decided to have a monitoring of arterial pressure with a femoral arterial catheter.
Related Therapeutic Areas
Sponsors
Leads: Hospices Civils de Lyon

This content was sourced from clinicaltrials.gov