Role of Transposable Elements in Septic Immune Aging
Status: Recruiting
Location: See location...
Intervention Type: Genetic
Study Type: Observational
SUMMARY
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Age 18 or older
• Admitted to ICU with sepsis (Sepsis 3 Criteria)
• SOFA score of at least 2 at time of enrollment
Locations
United States
California
University of California, San Francisco
RECRUITING
San Francisco
Contact Information
Primary
Alexendar R Perez, M.D., Ph.D
Alexendar.Perez@ucsf.edu
415-476-1000
Backup
Matthieu Legrand, M.D., Ph.D
matthieu.legrand@ucsf.edu
415-476-1000
Time Frame
Start Date: 2025-02-14
Estimated Completion Date: 2026-08-14
Participants
Target number of participants: 116
Treatments
Patients with Sepsis
Adult patients (age 18 and older) admitted to the intensive care unit (ICU) meeting Sepsis 3 Criteria.
Healthy Individual Controls
Healthy individuals not admitted to the hospital.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Francisco
Collaborators: National Cancer Institute (NCI)