Exploratory Study on Transcutaneous Auricular Vagus Nerve Stimulation as Adjuvant Treatment for Sepsis Patients

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goals of this randomized clinical trial are to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) combined with standard intensive care on systemic organ function in septic patients, and exploring its potential mechanisms for improving overall outcomes in sepsis.The main question it aims to answer is whether taVNS can reduce the severity of sepsis patients by ameliorating systemic inflammation.Participants will receive standard intensive care treatment and be randomized to receive the taVNS or sham taVNS as adjuvant treatment twice a day for 7 consecutive days. Several evaluations will be done before and after the intervention.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 18-80

• Sepsis was diagnosed per the Sepsis-3 criteria (SCCM/ESICM 2016) as infection with SOFA score ≥ 2

• ICU admission within 7 days after sepsis onset

• Informed consent was obtained from patients/guardians

Locations
Other Locations
China
The First Affiliated Hospital of Army Medical University
RECRUITING
Chongqing
Contact Information
Primary
Hong Yang, PhD
YHeasun@163.com
+8618580262250
Time Frame
Start Date: 2025-02-27
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 60
Treatments
Experimental: taVNS group
transcutaneous auricular vagus nerve stimulation twice a day for 7 consecutive days.
Sham_comparator: sham-taVNS group
sham transcutaneous auricular vagus nerve stimulation twice a day for 7 consecutive days.
Related Therapeutic Areas
Sponsors
Leads: Third Military Medical University

This content was sourced from clinicaltrials.gov