INflammation and Small Vessel Disease Study
A prospective observational cohort study in patients with cerebral small vessel disease deterring whether changes in systemic inflammation predict brain white matter damage measured using MRI and cognitive decline. This is a study funded by a joint BHF-Dutch Heart Foundation research grant and will be conducted in both Cambridge UK and Nijmegen Netherlands with 100 of the 200 total participants recruited at each site, and data from both sites analysed together.
• Have given written informed consent to participate
• Be aged 40 years and over
• Have symptomatic cerebral small vessel disease (SVD) defined as:
• Clinical lacunar stroke syndrome with lacunar infarct, as defined by the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) criteria
• And/OR Symptoms of cognitive impairment due to SVD with lacunar infarct on MRI
• And/OR Gait apraxia/motor impairment presumed due to SVD with lacunar infarct on MRI