Investigating the Use of a Brain-computer Interface Based on TMS Neurofeedback for Upper Limb Stroke Rehabilitation

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Phase 1
SUMMARY

The mechanisms and effectiveness of a technique to boost the brain's recovery mechanisms will be studied. Brain-Computer Interface (BCI),based on applying magnetic pulses (Transcranial Magnetic Stimulation, TMS) to the stroke damaged area in the brain, causing twitches in the paralysed muscles will be used. The size of these twitches are then displayed to the patient as neurofeedback (NF) on a computer screen in the form of a game. In the game, the aim for the patient is to learn how to make the twitches bigger by engaging appropriate mental imagery to re-activate the damaged brain region.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Be in the sub-acute phase (2-26 weeks) post stroke.

• Single hemisphere lesion

• No previous transient ischemic attack (TIA)

• Upper limb functional impairment (0-2 power)

• No or negligible OCS broken hearts test score (visual neglect)

• No or almost no cognitive impairment (Pass or near pass MMSE and MOCA)

• Passes TMS-Safety Questionnaire

• Detectable motor evoked potential (MEP) in response to TMS

Locations
Other Locations
Ireland
St James' Hospital
RECRUITING
Dublin
Contact Information
Primary
Kathy Ruddy, PhD
k.ruddy@qub.ac.uk
+44 7481811676
Backup
Lamia Tadjine, MSc
ltadjine@tcd.ie
+353 877623029
Time Frame
Start Date: 2023-06-01
Estimated Completion Date: 2025-08
Participants
Target number of participants: 20
Treatments
Active_comparator: TMS Neurofeedback
Participants in this Arm will receive TMS neurofeedback
Placebo_comparator: TMS Pseudofeedback
Participants in this Arm will receive TMS with pseudofeedback
Related Therapeutic Areas
Sponsors
Leads: University of Dublin, Trinity College
Collaborators: St. James Hospital

This content was sourced from clinicaltrials.gov