Movement-Associated tVNS and Responsiveness Testing for Personalized Rehabilitation
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this study is to learn about the acute pupil response to transcutaneous vagus nerve stimulation (tVNS) in stroke survivors and healthy adults. The main question it aims to answer is whether pupil size response is greater with bilateral tVNS compared to unilateral tVNS. Participants will receive tVNS and sham at the outer ear unilaterally and bilaterally in resting condition. The pupil size of the participants will be recorded during tVNS.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 89
Healthy Volunteers: t
View:
• 18-89 years old across all races, genders, and ethnicities.
• Post-stroke subjects will have persistent hemiparesis on the upper extremity (UE) with some residual UE voluntary movement.
Locations
United States
Georgia
Human Neuromuscular Physiology Lab
RECRUITING
Atlanta
Contact Information
Primary
Minoru Shinohara, Ph.D.
shinohara@gatech.edu
404-894-1030
Time Frame
Start Date: 2024-11-14
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 21
Treatments
Experimental: Unilateral Left tVNS
Electrical stimulation to the vagus nerve area of the outer ear on the left side.
Experimental: Bilateral tVNS
Electrical stimulation to the vagus nerve area of the outer ear on both sides.
Sham_comparator: Unilateral Left Sham
Electrical stimulation to the non-vagus nerve area of the outer ear on the left side.
Sham_comparator: Bilateral Sham
Electrical stimulation to the non-vagus nerve area of the outer ear on both sides.
Experimental: Unilateral Right tVNS
Electrical stimulation to the vagus nerve area of the outer ear on the right side.
Sham_comparator: Unilateral Right Sham
Electrical stimulation to the non-vagus nerve area of the outer ear on the right side.
Related Therapeutic Areas
Sponsors
Collaborators: Emory University, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Leads: Georgia Institute of Technology