• New focal neurologic deficit consistent with AIS

• National Institute of Health Stroke Scale (NIHSS) ≥4 or NIHSS\< 4 in the presence of disabling deficit (a deficit that, if unchanged, would prevent the

• patient from performing basic activities of daily living such as bathing, ambulating, toileting, hygiene, and eating or returning to work)

• Age\>18

• Presence of any cortical vessel occlusion, including Internal Carotid Artery, branches of Middle Cerebral Artery, Anterior Cerebral Artery, Posterior Cerebral Artery, Posterior-Inferior Cerebellar Artery

• Presence of salvageable penumbra with perfusion lesion volume to ischemic core volume ratio of ≥ 1.2 on multimodal imaging

• Patient ineligible for endovascular thrombectomy per American Heart/Stroke Associations Guidelines

• Patient is able to be treated with tDCS within 24 hours of last known well time

• A signed informed consent is obtained from the patient or patient's legally authorized representative

⁃ Additional inclusion criteria for non-thrombolytic patients

⁃ • Patient ineligible for IV lytics per American Heart/American Stroke Associations National Guidelines

⁃ Additional inclusion criteria for thrombolytic receiving patients

• Patient eligible for tPA per Guidelines

• Within 2-hours from intravenous thrombolytic start of administration