Bifocal Transcranial Alternating Current Stimulation Targeting the Frontoparietal Network in Stroke Patients to Enhance Network Connectivity

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Hand and arm function is often significantly impaired in stroke patients, making its recovery a primary goal in rehabilitative treatment. This study investigates the effects of bifocal transcranial alternating current stimulation (tACS) on the frontoparietal network in stroke patients during the subacute to chronic recovery phase. By using non-invasive brain stimulation, the study aims to modulate the neural network connectivity between the ipsilesional parietal and premotor cortices. Electroencephalography and kinematic data will be utilized to assess the impact of tACS on functional connectivity and its subsequent effect on motor function. The ultimate goal is to enhance functional coupling within these networks to promote motor function in stroke patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• First-ever clinical stroke

• Signed informed consent

• First-ever clinical ischemic stroke at least 3 months ago

• Stimulation areas (PMv and IPS) are unaffected

• Residual deficits in the upper limb

Locations
Other Locations
Germany
Department of Neurology, University Medical Center Hamburg-Eppendorf
RECRUITING
Hamburg
Contact Information
Primary
Fanny Quandt, Dr. med.
f.quandt@uke.de
+4974100
Backup
Robert Schulz, PD Dr. med.
r.schulz@uke.de
+4974100
Time Frame
Start Date: 2025-02-03
Estimated Completion Date: 2026-08
Participants
Target number of participants: 20
Treatments
Active_comparator: In-phase-tACS
Patients will perform a reach-to-grasp task with their affected hand during bifocal tACS targeting the aIPS and PMv of the lesioned hemisphere during three seperat sessions. The sequence of stimulation types will be randomized.
Active_comparator: Out-of-phase-tACS
Patients will perform a reach-to-grasp task with their affected hand during bifocal tACS targeting the aIPS and PMv of the lesioned hemisphere during three seperat sessions. The sequence of stimulation types will be randomized.
Sham_comparator: Sham -tACS
Patients will perform a reach-to-grasp task with their affected hand during bifocal tACS targeting the aIPS and PMv of the lesioned hemisphere during three seperat sessions. The sequence of stimulation types will be randomized.
Related Therapeutic Areas
Sponsors
Leads: Universitätsklinikum Hamburg-Eppendorf
Collaborators: Technical University of Twente

This content was sourced from clinicaltrials.gov

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