Cognitive Impairment Mechanisms and Training With Real Time-functional MRI Neurofeedback After Stroke
Post-stroke cognitive impairment (PSCI) is a common source of invisible disability. The actual techniques of cognitive remediation have been reported to have only a small effect, justifying the need to foster research in this field. Real-time functional MRI neurofeedack (rt-fMRI NF) is a procedure of brain-machine interface supporting self-regulation of brain activity, with promising results in the treatment of mental disorders. The main objective of the study is to evaluate in a pilot study, the ability of stroke patients to learn to self-regulate their brain activity in a priviledged direction, using rt-fMRI NF
• Men or women
• Right handed
• 18 ≤ years old \< 75
• first-ever ischemic stroke on brain MRI in the past 3 to 6 months ;
• Persisting cognitive complaint 3 months after the ischemic stroke, proved by a MoCA score ≤ 26 (if educational level ≥ 12 years, or ≤ 25 if educational level \< 12 years), and involving at least one of the following cognitive domains : executive functions, attention, and processing speed ;
• Ischemic stroke located in the territory of the middle cerebral artery and /or basal ganglia/thalamus ;
• NIHSS ≤ 5, without aphasia or severe visual disability empeding the understanding of the instructions, the neurofeedback task achievement, and/or the neuropsychological assessment ;
• No prestroke disability defined by a modified Rankin Scale ≤ 2 ;
• For women of childbearing potential, use of effective contraception and negative pregnancy test.
• Written informed consent by the patient.
• Coverage by the French Social Insurance