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Frequency-Dependent Effects of Percutaneous Femoral Nerve Stimulation on Strength in Athletes With Patellar Tendinopathy: a Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study investigates the immediate effects of different peripheral electrical nerve stimulation protocols applied to the femoral nerve on quadriceps strength in athletes with patellar tendinopathy. Patellar tendinopathy is a common overuse injury that often reduces quadriceps activation and limits sports performance. Peripheral percutaneous nerve stimulation (PPNS) and transcutaneous electrical nerve stimulation (TENS) are frequently used in rehabilitation, but their frequency-dependent effects on muscle strength are not well established. In this randomized crossover trial, each participant receives three stimulation protocols in separate sessions: high-frequency PPNS (100 Hz), low-frequency PPNS (2 Hz), and conventional TENS. All stimulation is delivered at the maximal tolerated motor threshold and, for PPNS conditions, under ultrasound guidance. Quadriceps maximal isometric strength is evaluated using an isometric force sensor before and after each intervention. The primary objective is to compare the acute changes in maximal voluntary contraction (MVC) following each stimulation protocol. The study aims to clarify whether different stimulation frequencies can enhance, reduce, or have no effect on quadriceps strength in this athletic population. By identifying frequency-specific neuromodulatory responses, this study may help clinicians and sports practitioners select the most appropriate stimulation parameters to optimize rehabilitation and performance in individuals with patellar tendinopathy.

Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Maximum Age: 40
Healthy Volunteers: f
View:

• Adults aged 18 to 40 years.

• Recreational or competitive athletes with clinically diagnosed patellar tendinopathy for at least 3 months.

• Ultrasound-confirmed patellar tendinopathy, including hypoechoic areas, tendon thickening, or neovascularization consistent with clinical diagnosis.

⁃ Presence of pain during tendon-loading activities (e.g., jumping, running, squatting).

• Ability to perform maximal voluntary isometric contractions of the quadriceps.

• Ability to comply with all study procedures and attend all experimental sessions.

• Written informed consent obtained prior to participation.

Locations
Other Locations
Spain
Blanquerna University
RECRUITING
Barcelona
Contact Information
Primary
Javier Picañol Parraga Picañol, Phd
xpicanol@ub.edu
+34655394127
Time Frame
Start Date: 2025-09-20
Estimated Completion Date: 2025-12-15
Participants
Target number of participants: 19
Treatments
Experimental: High-Frequency PPNS (100 Hz)
Participants receive peripheral percutaneous nerve stimulation (PPNS) applied to the femoral nerve at 100 Hz.
Experimental: Low-Frequency PPNS (2 Hz)
Participants receive peripheral percutaneous nerve stimulation (PPNS) applied to the femoral nerve at 2 Hz.
Active_comparator: Transcutaneous Electrical Nerve Stimulation (TENS)
Participants receive conventional transcutaneous electrical nerve stimulation (TENS) applied over the femoral nerve region using surface electrodes. Intensity is set at the maximal tolerated motor threshold to elicit visible quadriceps activation. The stimulation frequency and parameters are consistent with standard clinical practice for motor-level TENS.
Related Therapeutic Areas
Sponsors
Leads: Hospital Clinic of Barcelona

This content was sourced from clinicaltrials.gov