Physician Initiated Trial Investigating ESAR (EVAR Plus Heli-FX EndoAnchors) and FEVAR for the Treatment of Aortic Aneurysms With Short Infrarenal Aortic Neck

Who is this study for? Patients with aortic aneurysms with short infrarenal aortic neck
Status: Recruiting
Location: See all (32) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The aim of this randomized study is to compare the safety and performance of EndoVascular Aneurysm Repair with ESAR using Endurant + Heli-FX™ EndoAnchor™ system and FEVAR using customizable grafts from Cook (Zenith Fenestrated Graft) and Terumo (Fenestrated Anaconda Graft) for the treatment of aortic aneurysms with short aortic neck (4 to 15mm).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Subject is \>18 years old

• Subject is scheduled for primary treatment of the abdominal aortic aneurysm with a non-aneurysmal infrarenal aortic sealing zone proximal to the aneurysm that is sufficiently healthy for a proximal neck length that is at least 4mm and not more than15 mm and has a circumferential minimum sealing zone length of 8 mm

• Subject is not a candidate for safe, effective and durable standard EVAR due to challenging anatomical criteria as confirmed by the Core Lab screening

• Subject is able and willing to comply with the protocol and to adhere to the follow-up requirements.

• Subject has provided written informed consent

⁃ CT Angiographic Inclusion Criteria

• Subject meets the other anatomical requirements according to the locally applicable Endurant II/IIs stent graft system, Heli-FX EndoAnchor system, Terumo Fenestrated Anaconda (available in EU only) and/or Cook Zenith Fenestrated Graft Instructions for Use

• Proximal neck length of the aorta within 4-15mm and a minimum circumferential sealing zone of 8mm

• Aortic neck diameter from 19 to 31mm

• Infrarenal neck angulation ≤45°

Locations
United States
California
UCSD Medical Center Hillcrest
RECRUITING
La Jolla
Stanford University
RECRUITING
Stanford
Florida
University of Florida
RECRUITING
Gainesville
Michigan
Corewell Health (Spectrum)
RECRUITING
Grand Rapids
North Carolina
Atrium Health Carolinas Medical Center
RECRUITING
Charlotte
New York
Mount Sinai Hospital
RECRUITING
New York
Oklahoma
Oklahoma Heart
RECRUITING
Tulsa
Oregon
Providence Portland Medical Center
RECRUITING
Portland
Pennsylvania
Allegheny General Hospital
RECRUITING
Pittsburgh
Virginia
Sentara Norfolk General Hospital
RECRUITING
Norfolk
Other Locations
Austria
Hospital Ottakring, Institute for Vascular Surgery
RECRUITING
Vienna
Belgium
CRC thoracic Vascular Surgery, ZOL Genk
RECRUITING
Genk
Universitair Ziekenhuis Gent, Thoracale en vasculaire heelkunde
RECRUITING
Ghent
France
Amrois Paré Hospital (APHP)
RECRUITING
Boulogne
Service de Chirurgie Vasculaire et Endovasculaire CHU Gabriel-Montpied 58 rue Montalembert
RECRUITING
Clermont-ferrand
Hospices Civils de lyon - Hôpital Edouard Herriot
RECRUITING
Lyon
Centre Hospitalier Universitaire de Rennes
RECRUITING
Rennes
Germany
University Hospital RWTH Aachen
RECRUITING
Aachen
University Hospital Leipzig
RECRUITING
Leipzig
Martin Austermann
ACTIVE_NOT_RECRUITING
Münster
Italy
University of Bologna, IRCCS S. Orsola Hospital,
RECRUITING
Bologna
Az. Ospedaliera San Martino, Genova
RECRUITING
Genova
IRCCS Ospedale San Raffaele, Chirurgia Vascolare
RECRUITING
Milan
Vascular Endovascular Surgery University of Perugia;
NOT_YET_RECRUITING
Perugia
Az.Osped.Univers.S.Giovanni, Turin
RECRUITING
Turin
Netherlands
VUMC Amsterdam
NOT_YET_RECRUITING
Amsterdam
Catharina Ziekenhuis
NOT_YET_RECRUITING
Eindhoven
Poland
National Institute of Cardiology Warzwa
RECRUITING
Warsaw
Spain
Hospital Ramon Y Cajal
RECRUITING
Madrid
Hospital Universitario Donostia
RECRUITING
San Sebastián
HOSPITAL CLINICO UNIVERSITARIO Valladolid
RECRUITING
Valladolid
Switzerland
Inselspital Bern, Universitätsklinik für Gefässchirurgie
NOT_YET_RECRUITING
Bern
Contact Information
Primary
Sarah Litterscheid, PhD
info@fcre.eu
+49 15785319015
Backup
Sarah Litterscheid
sarah.litterscheid@fcre.eu
+49 15785319015
Time Frame
Start Date: 2021-05-21
Estimated Completion Date: 2028-06-01
Participants
Target number of participants: 204
Treatments
Experimental: ESAR
Endovascular Aneurysm Repair + Heli-FX EndoAnchors
Active_comparator: FEVAR
Fenestrated EndoVascular Aneurysm Repair
Sponsors
Collaborators: Medtronic
Leads: FCRE (Foundation for Cardiovascular Research and Education)

This content was sourced from clinicaltrials.gov