Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Observational
SUMMARY
The main objective of this study is to utilize Magnetic Resonance Elastography (MRE) to determine tissue stiffness of abdominal aortic aneurysms (AAA). For patients with AAA, MRE is a more sensitive and superior method of determining the risk for rupture of AAA based on stiffness estimates when compared to the current, crude method of assessing risk based on measurement of the diameter of the aneurysm. The investigators will also validate the stiffness estimates against gold standard i.e. mechanical testing and histopathology only AAA patients undergoing AAA surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Healthy Volunteers: t
View:
• Must be able to lie flat on their back in the scanner for up to 60 minutes
• Must be able to hold breath for up to 15 seconds
Locations
United States
Ohio
The Ohio State University Medical Center
RECRUITING
Columbus
Contact Information
Primary
Kristin L Thompson, B.S.
Kristin.Thompson@osumc.edu
614-366-5429
Time Frame
Start Date: 2014-10
Estimated Completion Date: 2028-10-31
Participants
Target number of participants: 165
Treatments
Normal Volunteers
60 normal volunteers will be recruited. Each volunteer will undergo a single MRE scan (with Resoundant driver System ) of their abdominal aorta.
Patients with AAA
Fifty to sixty five patients with AAA will be recruited. These patients will undergo MRE (with Resoundant driver system) of their AAA every six months for three years, or until the study ends or until the time of surgical repair or death due to rupture of AAA or other causes.
Open Surgical Repair Patients
Fifty to sixty five patients patients undergoing open surgical repair will be recruited and undergo MRE (with Resoundant driver system) prior to surgery
Related Therapeutic Areas
Sponsors
Leads: Ohio State University