Learn About Acanthosis Nigricans
Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases.
AN; Skin pigment disorder - acanthosis nigricans
AN can affect otherwise healthy people. It can also be related to medical problems, such as:
- Genetic disorders, including Down syndrome and Alström syndrome
- Hormone imbalances that occur in diabetes and obesity
- Cancer, such as cancer of the digestive system, liver, kidney, bladder, or lymphoma
- Some medicines, including hormones such as human growth hormone or birth control pills
AN usually appears slowly and doesn't cause any symptoms other than skin changes.
Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes.
Sometimes, the lips, palms, soles of the feet, or other areas are affected. These symptoms are more common in people with cancer.
No treatment is needed, as AN only causes a change in skin color. If the condition is affecting your appearance, using moisturizers containing ammonium lactate, tretinoin, or hydroquinone can help lighten the skin. Your provider may also suggest laser treatment.
It is important to treat any underlying medical problem that may be causing these skin changes. When AN is related to obesity, losing weight often improves the condition.
University Of Melbourne
Ravi Savarirayan is in Parkville, Australia. Savarirayan is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 35 other conditions, according to our data. His top areas of expertise are Achondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Chondrodystrophy.
Showa Ku
Masaki Matsushita is in Nagoya, Japan. Matsushita is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Acanthosis Nigricans, Type A Insulin Resistance Syndrome, Achondroplasia, and Hypochondroplasia.
Showa Ku
Hiroshi Kitoh is in Nagoya, Japan. Kitoh is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 23 other conditions, according to our data. His top areas of expertise are Hypochondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Achondroplasia.
AN often disappears if the cause can be found and treated.
Call your provider if you develop areas of thick, dark, velvety skin.
Published Date : April 10, 2020
Published By : Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
Dinulos JGH. Cutaneous manifestations of internal disease. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 26.
Patterson JW. Miscellaneous conditions. In: Patterson JW, ed. Weedon's Skin Pathology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 20.