Learn About Acanthosis Nigricans

What is the definition of Acanthosis Nigricans?

Acanthosis nigricans (AN) is a skin disorder in which there is darker, thick, velvety skin in body folds and creases.

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What are the alternative names for Acanthosis Nigricans?

AN; Skin pigment disorder - acanthosis nigricans

What are the causes of Acanthosis Nigricans?

AN can affect otherwise healthy people. It can also be related to medical problems, such as:

  • Genetic disorders, including Down syndrome and Alström syndrome
  • Hormone imbalances that occur in diabetes and obesity
  • Cancer, such as cancer of the digestive system, liver, kidney, bladder, or lymphoma
  • Some medicines, including hormones such as human growth hormone or birth control pills
What are the symptoms of Acanthosis Nigricans?

AN usually appears slowly and doesn't cause any symptoms other than skin changes.

Eventually, dark, velvety skin with very visible markings and creases appears in the armpits, groin and neck folds, and over the joints of the fingers and toes.

Sometimes, the lips, palms, soles of the feet, or other areas are affected. These symptoms are more common in people with cancer.

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What are the current treatments for Acanthosis Nigricans?

No treatment is needed, as AN only causes a change in skin color. If the condition is affecting your appearance, using moisturizers containing ammonium lactate, tretinoin, or hydroquinone can help lighten the skin. Your provider may also suggest laser treatment.

It is important to treat any underlying medical problem that may be causing these skin changes. When AN is related to obesity, losing weight often improves the condition.

Who are the top Acanthosis Nigricans Local Doctors?
Elite
Highly rated in
35
conditions

University Of Melbourne

Parkville, VIC, AU 

Ravi Savarirayan is in Parkville, Australia. Savarirayan is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 35 other conditions, according to our data. His top areas of expertise are Achondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Chondrodystrophy.

Elite
Highly rated in
14
conditions

Showa Ku

Nagoya University Graduate School Of Medicine 
Nagoya, JP 

Masaki Matsushita is in Nagoya, Japan. Matsushita is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 14 other conditions, according to our data. His top areas of expertise are Acanthosis Nigricans, Type A Insulin Resistance Syndrome, Achondroplasia, and Hypochondroplasia.

 
 
 
 
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Elite
Highly rated in
23
conditions

Showa Ku

Department Of Orthopaedic Surgery, Nagoya University Graduate School Of Medicine 
Nagoya, JP 

Hiroshi Kitoh is in Nagoya, Japan. Kitoh is rated as an Elite expert by MediFind in the treatment of Acanthosis Nigricans. He is also highly rated in 23 other conditions, according to our data. His top areas of expertise are Hypochondroplasia, Type A Insulin Resistance Syndrome, Acanthosis Nigricans, and Achondroplasia.

What is the outlook (prognosis) for Acanthosis Nigricans?

AN often disappears if the cause can be found and treated.

When should I contact a medical professional for Acanthosis Nigricans?

Call your provider if you develop areas of thick, dark, velvety skin.

Acanthosis nigricans - close-up
Acanthosis nigricans on the hand
What are the latest Acanthosis Nigricans Clinical Trials?
Study of the Effect of Fractional co2 Laser Versus Q Switched:NdYAG Laser in the Treatment of Acanthosis Nigricans
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Phase 2, Open-Label, Dose-Escalation and Dose-Expansion Study of Infigratinib, an FGFR 1-3-Selective Tyrosine Kinase Inhibitor, in Children With Achondroplasia: PROPEL 2
What are the Latest Advances for Acanthosis Nigricans?
Correlation between total testosterone levels and insulin resistance in patients with acanthosis nigricans and non-acanthosis nigrican.
A Case of Nevoid Acanthosis Nigricans Successfully Treated with Topical Ketoconazole Plus Urea.
Tired of the same old research?
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Upregulated Guanine Deaminase Is Involved in Hyperpigmentation of Seborrheic Keratosis via Uric Acid Release.
Who are the sources who wrote this article ?

Published Date : April 10, 2020
Published By : Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Dinulos JGH. Cutaneous manifestations of internal disease. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 26.

Patterson JW. Miscellaneous conditions. In: Patterson JW, ed. Weedon's Skin Pathology. 5th ed. Philadelphia, PA: Elsevier; 2021:chap 20.