Achalasia Clinical Trials

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PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders

Status: Recruiting
Location: See all (13) locations...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Age ≥ 18

• Type I achalasia or type II achalasia or cEGJOO

• Eckardt score \> 3

Locations
United States
Arizona
Mayo Clinic Arizona
NOT_YET_RECRUITING
Scottsdale
California
University of California San Diego
NOT_YET_RECRUITING
La Jolla
Colorado
University of Colorado Denver
NOT_YET_RECRUITING
Denver
Florida
University of Florida
NOT_YET_RECRUITING
Gainesville
Adventist Health System/Sunbelt, Inc
NOT_YET_RECRUITING
Orlando
Georgia
Emory University
NOT_YET_RECRUITING
Atlanta
Illinois
Northwestern University
RECRUITING
Chicago
Maryland
Johns Hopkins University
NOT_YET_RECRUITING
Baltimore
Missouri
Washington University
NOT_YET_RECRUITING
St Louis
New York
Weill Cornell Medical College
NOT_YET_RECRUITING
New York
Ohio
Case Western Reserve University
NOT_YET_RECRUITING
Cleveland
Tennessee
Vanderbilt University Medical Center
NOT_YET_RECRUITING
Nashville
Texas
Baylor Scott & White Health
NOT_YET_RECRUITING
Dallas
Contact Information
Primary
Elizabeth Yan, BS
elizabeth.yan@northwestern.edu
312-908-1723
Backup
Yasmin Pina, BS
yasmin.pina@northwestern.edu
312-503-6459
Time Frame
Start Date: 2026-04-23
Estimated Completion Date: 2030-03-01
Participants
Target number of participants: 372
Treatments
Active_comparator: Standard Myotomy
Experimental: Tailored Short Myotomy
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: Northwestern University

This content was sourced from clinicaltrials.gov