PREcision MEDicine In Achalasia - A Multicenter Randomized Non-Inferiority Clinical Trial of Short Tailored POEM vs. Standard POEM for Non-Spastic Achalasia and A Multicenter Prospective Cohort Study of Long Tailored POEM for Spastic Esophageal Motility Disorders
Status: Recruiting
Location: See all (13) locations...
Study Type: Observational
SUMMARY
The goal of this observational study is to learn about how the doctor decides how long to cut t the esophageal muscle during Per-Oral Endoscopic Myotomy (POEM) in patients with difficulty swallowing due to certain conditions. The main question it aims to answer is: does pre-POEM testing help the physician choose how long to cut the muscle. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age ≥ 18
• Type III achalasia or EGJOO with spastic/hypercontractile features or Jackhammer Esophagus or Distal Esophageal Spasm
• Eckardt Score \> 3
Locations
United States
Arizona
Mayo Clinic Arizona
NOT_YET_RECRUITING
Scottsdale
California
University of California San Diego
NOT_YET_RECRUITING
La Jolla
Colorado
University of Colorado Denver
NOT_YET_RECRUITING
Denver
Florida
University of Florida
NOT_YET_RECRUITING
Gainesville
Adventist Health System/Sunbelt, Inc
NOT_YET_RECRUITING
Orlando
Georgia
Emory University
NOT_YET_RECRUITING
Atlanta
Illinois
Northwestern University
RECRUITING
Chicago
Maryland
Johns Hopkins University
NOT_YET_RECRUITING
Baltimore
Missouri
Washington University
NOT_YET_RECRUITING
St Louis
New York
Weill Cornell Medical College
NOT_YET_RECRUITING
New York
Ohio
Case Western Reserve University
NOT_YET_RECRUITING
Cleveland
Tennessee
Vanderbilt University Medical Center
NOT_YET_RECRUITING
Nashville
Texas
Baylor Scott & White Health
NOT_YET_RECRUITING
Dallas
Contact Information
Primary
Elizabeth Yan, BS
elizabeth.yan@northwestern.edu
312-908-1723
Backup
Yasmin Pina, BS
yasmin.pina@northwestern.edu
312-503-6459
Time Frame
Start Date: 2026-06-01
Estimated Completion Date: 2030-03-01
Participants
Target number of participants: 200
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Leads: Northwestern University