Learn About Achard Syndrome

What is the definition of Achard Syndrome?
Achard syndrome, also known as Achard-Thiers syndrome, is a rare disorder characterized by the development of type 2 diabetes mellitus combined with symptoms of androgen (male trait hormone) overproduction, such as excessive facial and body hair. Achard syndrome most often occurs in postmenopausal women but can also occur in female adolescents and young women.
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What are the symptoms of Achard Syndrome?
Symptoms of Achard syndrome appear as the onset of type 2 diabetes, for which symptoms may include excessive thirst and appetite, weight loss, high glucose levels in urine, frequent urination, and symptoms of androgen overproduction, such as excess body hair (hirsutism), especially facial hair such as the development of a beard, receding hairline, deeper voice, clitoral enlargement, obesity, and infertility. Additional symptoms may include absent, infrequent, or very light menstruation, and acanthosis nigricans (darkening in skin folds). In female adolescents or young women, Achard may also be diagnosed as polycystic ovary syndrome (PCOS).
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What are the current treatments for Achard Syndrome?
Treatment for Achard syndrome includes diet therapy and/or insulin or other diabetes medications and oral contraceptives to control androgen overproduction in young women. Postmenopausal women with Achard syndrome are treated with hormone replacement therapy. Some individuals with Achard syndrome may be treated with anti-androgen therapy. Excess facial and body hair can be removed with cosmetic treatments, such as electrolysis or waxing.
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What are the latest Achard Syndrome Clinical Trials?
Constitution of a Biological Collection to Study the Pathophysiology in Marfan Syndrome and Related Syndromes and to Identify Predictive Factors of Disease Progression

Summary: The present study will establish a collection of biological samples from Marfan patients or with associated diseases to be used for research purposes only, with due respect for confidentiality.

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Immunopathology of Loeys-Dietz Syndrome

Summary: Loeys-Dietz syndrome (LDS) is a rare vascular genetic disorder (estimated prevalence 1/25,000-1/100,000) due primarily to mutations in the Transforming growth factor beta (TGF-β) cytokine receptor 1 and 2 genes. In addition to a common vascular phenotype with Marfan syndrome (dilatation of the ascending aorta, arachnodactyly, lens dislocation), patients present specific malformations (bifid uvula,...

What are the Latest Advances for Achard Syndrome?
Marfan syndrome and related disorders.
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