Acquired Agranulocytosis Symptoms, Doctors, Treatments, Advances & More

Acquired Agranulocytosis Overview

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Learn About Acquired Agranulocytosis

What is the definition of Acquired Agranulocytosis?

Acquired agranulocytosis is a rare disorder characterized by a severe decrease in white blood cells (granulocytes) and is usually caused by drugs used to treat cancer, such as chemotherapy, and antipsychotic medications, such as clozapine, which interfere with the production of granulocytes in the bone marrow. The decrease in granulocytes makes individuals with acquired agranulocytosis more susceptible to bacteria infections from bacteria that would otherwise not be considered harmful in a healthy individual.

What are the symptoms of Acquired Agranulocytosis?

Early symptoms of acquired agranulocytosis are usually a bacterial infection that may include weakness, extreme fatigue, fever, chills, and infected ulcerations in the mucous membranes of the mouth, throat, and intestinal tract, along with difficulty swallowing (dysphagia) and irritation, pain, and swelling due to the ulcers. As the reduction in granulocytes (granulocytopenia) continues, patients with acquired agranulocytosis may develop an enlarged spleen (splenomegaly) and neutropenia (decreased blood neutrophils). In addition to the early symptoms, individuals with chronic acquired agranulocytosis may experience the development of canker sores in the mouth and gingivitis (inflammation of the gums) that regularly recurs.

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What are the current treatments for Acquired Agranulocytosis?

The standard treatment for acquired agranulocytosis is the drug, filgrastim (Neupogen), in addition to identifying and discontinuing other drugs that may be causing the disorder. Some patients with acquired agranulocytosis may require treatment with antibiotics or corticosteroid therapy for associated bacterial infections. Immunocompromised patients with acquire agranulocytosis may require gamma globulin infusions. The associated mouth and throat ulcers can be treated with saline or hydrogen peroxide gargles, anesthetic lozenges, and antifungal mouthwashes containing the drug, nystatin, for oral fungal infections, such as thrush or Candida albicans (yeast infection). A liquid diet may be necessary until the ulcers heal. Acquired agranulocytosis will usually resolve once the granulocyte levels return to normal.

Who are the top Acquired Agranulocytosis Local Doctors?

Advanced in Acquired Agranulocytosis

Dr. Marwan Mounayar

Hematology Oncology | Hematology | Oncology

Advanced in Acquired Agranulocytosis

Dr. Marwan Mounayar

Hematology Oncology | Hematology | Oncology

Indiana University Health Ball Memorial Physicians Inc

2401 W University Ave,

Muncie, IN

765-747-3111

Languages Spoken:

English

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Accepting New Patients

Marwan Mounayar is a Hematologist Oncology specialist and a Hematologist in Muncie, Indiana. Dr. Mounayar is rated as an Advanced provider by MediFind in the treatment of Acquired Agranulocytosis. His top areas of expertise are Lung Cancer, Pleuropulmonary Blastoma, Small Cell Lung Cancer (SCLC), and Intraductal Papilloma. Dr. Mounayar is currently accepting new patients.

Advanced in Acquired Agranulocytosis

Dr. Jonathan J. Gries

Family Medicine

Advanced in Acquired Agranulocytosis

Dr. Jonathan J. Gries

Family Medicine

Baptist Primary Care Inc

141 Hilden Rd, Suite 201,

Ponte Vedra, FL

904-825-1941

Languages Spoken:

English

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Accepting New Patients

Offers Telehealth

Jonathan Gries is a primary care provider, practicing in Family Medicine in Ponte Vedra, Florida. Dr. Gries is rated as an Advanced provider by MediFind in the treatment of Acquired Agranulocytosis. His top areas of expertise are Type B Insulin Resistance Syndrome, Abdominal Obesity Metabolic Syndrome, Cytochrome C Oxidase Deficiency, and Mitochondrial Complex V Deficiency. Dr. Gries is currently accepting new patients.

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Advanced in Acquired Agranulocytosis

Dr. Michelle Fiorillo

Family Medicine

Advanced in Acquired Agranulocytosis

Dr. Michelle Fiorillo

Family Medicine

Holy Cross Hospital Inc

1100 E Broward Blvd, Holy Cross Medical Group,

Ft Lauderdale, FL

954-463-5271

Languages Spoken:

English, French, Spanish

See accepted insurances

Accepting New Patients

Offers Telehealth

Michelle Fiorillo is a primary care provider, practicing in Family Medicine in Ft Lauderdale, Florida. Dr. Fiorillo is rated as an Advanced provider by MediFind in the treatment of Acquired Agranulocytosis. Her top areas of expertise are High Cholesterol, Acquired Agranulocytosis, Glucocorticoid-Remediable Aldosteronism, and Hypertension. Dr. Fiorillo is currently accepting new patients.