What is the definition of Acquired Amegakaryocytic Thrombocytopenia?

Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds. There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people. 

What are the alternative names for Acquired Amegakaryocytic Thrombocytopenia?

  • Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
  • AAT
  • Acquired pure megakaryocytic aplasia

What are the causes for Acquired Amegakaryocytic Thrombocytopenia?

There are many potential causes of acquired amegakaryocytic thrombocytopenia. For example, the condition can be associated with:
  • Viral infections
  • Bacterial infections
  • Chemotherapy
  • Exposure to environmental toxins
  • Autoimmune diseases (i.e. systemic lupus erythematosus)
  • Drug sensitivities
  • Pregnancy

In some people, the condition is an early sign of a more severe progressive disease, such as aplastic anemia, myelodysplasia, or leukemia.

What are the symptoms for Acquired Amegakaryocytic Thrombocytopenia?

The signs and symptoms of acquired amegakaryocytic thrombocytopenia vary but may include:
  • Prolonged bleeding, even from minor cuts
  • Easy bruising
  • Rash (pinpoint red spots called petechia)
  • Bleeding in the mouth and gums
  • Frequent nosebleeds

What are the current treatments for Acquired Amegakaryocytic Thrombocytopenia?

Standard treatment guidelines have not been established for acquired amegakaryocytic thrombocytopenia. However, various immunosuppressive treatment approaches have been utilized in affected people. In several case reports, affected people were successfully treated with cyclosporine either alone or in combination with other immunosuppressive medications (i.e. antithymocyte globulin). Other therapies for acquired amegakaryocytic thrombocytopenia have included rituximab, danazol, azathioprine, and bone marrow transplant with variable success.

To determine the best treatment for you or a family member, please speak with a healthcare provider.

What is the outlook (prognosis) for Acquired Amegakaryocytic Thrombocytopenia?

The long-term outlook (prognosis) for people with acquired amegakaryocytic thrombocytopenia varies based on the underlying cause. Some people respond well to treatment and long-term remissions have been documented in several case reports. In others, the condition progresses rapidly to aplastic anemia or myelodysplasia. There are currently no good predictors to aid in assessing the likelihood of response to therapy or overall prognosis.

How is Acquired Amegakaryocytic Thrombocytopenia diagnosed?

A diagnosis of acquired amegakaryocytic thrombocytopenia is often suspected based on the presence of characteristic signs and symptoms. Additional testing can then be ordered to confirm the diagnosis. This may include:
  • Complete blood count (CBC)
  • Blood smear
  • Blood clotting studies (PTT and PT)
  • Bone marrow tests (i.e. a bone marrow aspiration and/or biopsy)

Once the diagnosis is confirmed, a healthcare provider will likely recommend other tests in an attempt to determine the underlying cause of the condition.
  • Condition: Thymoma and Pure Red Cell Aplasia with Hypoplasia of Megakaryocytopoiesis
  • Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
  • Treatment Used: Medical Treatment
  • Number of Patients: 1
  • Published —
This case report discusses a 62-year-old female diagnosed with thymoma (thymus tumor) and pure red cell aplasia with hypoplasia of megakaryocytopoiesis (blood condition) treated with some lines of medical treatment.
  • Condition: Acquired Amegagakaryocytic Thrombocytopenia )AAMT) and Red Cell Aplasia in Patient with Thymoma Progressing to Aplastic Anemia (AA)
  • Journal: Hematology/oncology and stem cell therapy
  • Treatment Used: Allogenic Stem Cell Transplantation (allo-SCT)
  • Number of Patients: 1
  • Published —
This case report discusses a patient with thymoma complicated by pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT) who progressed to develop aplastic anemia (AA) treated with allogeneic stem cell transplantation (allo-SCT).