Acromegaly is a condition in which there is too much growth hormone (GH) in the body.
Somatotroph adenoma; Growth hormone excess; Growth hormone secreting pituitary adenoma; Pituitary giant (in childhood)
Acromegaly is a rare condition. It is caused when the pituitary gland makes too much growth hormone. The pituitary gland is a small endocrine gland attached to the bottom of the brain. It controls, makes, and releases several hormones, including growth hormone.
Usually, a noncancerous (benign) tumor of the pituitary gland releases too much growth hormone. In rare cases, pituitary tumors can be inherited.
In children, too much GH causes gigantism rather than acromegaly.
Symptoms of acromegaly may include any of the following:
Other symptoms that may occur with this disease:
Surgery to remove the pituitary tumor that is causing this condition often corrects the abnormal GH. Sometimes, the tumor is too large to be removed completely and acromegaly is not cured. In this case, medicines and radiation (radiotherapy) may be used to treat acromegaly.
Some people with tumors that are too complicated to remove by surgery are treated with medicines instead of surgery. These medicines may block the production of GH from the pituitary gland or prevent the action of GH in other parts of the body.
After treatment, you will need to see your provider regularly to make sure that the pituitary gland is working normally and that acromegaly does not come back. Yearly evaluations are recommended.
More information and support for people with acromegaly and their families can be found at:
Pituitary surgery is successful in most people, depending on the size of the tumor and the experience of the neurosurgeon with pituitary tumors.
Without treatment, the symptoms will get worse. Conditions such as high blood pressure, diabetes, and heart disease may result.
Call your provider if:
Acromegaly cannot be prevented. Early treatment may prevent the disease from getting worse and help to avoid complications.
Published Date: May 13, 2021
Published By: Brent Wisse, MD, Board Certified in Metabolism/Endocrinology, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
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