Learn About Actinic Keratosis
Actinic keratosis is a small, rough, raised area on your skin. Often this area has been exposed to the sun over a long period of time.
Some actinic keratoses may develop into a type of skin cancer.
Solar keratosis; Sun-induced skin changes - keratosis; Keratosis - actinic (solar); Skin lesion - actinic keratosis
Actinic keratosis is caused by exposure to sunlight.
You are more likely to develop it if you:
- Have fair skin, blue or green eyes, or blond or red hair
- Had a kidney or other organ transplant
- Take medicines that suppress the immune system
- Spend a lot of time each day in the sun (for example, if you work outdoors)
- Had many severe sunburns early in life
- Are older
Actinic keratosis is usually found on the face, scalp, back of the hands, chest, or places that are often in the sun.
- The skin changes begin as flat and scaly areas. They often have a white or yellow crusty scale on top.
- The growths may be gray, pink, red, or the same color as your skin. Later, they may become hard and wart-like or gritty and rough.
- The affected areas may be easier to feel than see.
Some actinic keratoses become squamous cell skin cancer. Have your provider look at all skin growths as soon as you find them. Your provider will tell you how to treat them.
Growths may be removed by:
- Burning (electrical cautery)
- Scraping away the lesion and using electricity to kill any remaining cells (called curettage and electrodesiccation)
- Cutting the tumor out and using stitches to place the skin back together (called excision)
- Freezing (cryotherapy, which freezes and kills the cells)
If you have many of these skin growths, your provider may recommend:
- A special light treatment called photodynamic therapy
- Chemical peels
- Skin creams, such as 5-fluorouracil (5-FU) and imiquimod
Markus Heppt practices in Dresden, Germany. Mr. Heppt is rated as an Elite expert by MediFind in the treatment of Actinic Keratosis. His top areas of expertise are Actinic Keratosis, Melanoma, Metastatic Uveal Melanoma, Bowen's Disease, and Bone Marrow Aspiration.
Cleveland Clinic Main Campus
Edward Maytin is a Dermatologist in Cleveland, Ohio. Dr. Maytin has been practicing medicine for over 47 years and is rated as an Elite provider by MediFind in the treatment of Actinic Keratosis. His top areas of expertise are Squamous Cell Skin Carcinoma, Actinic Keratosis, Nevoid Basal Cell Carcinoma Syndrome, and Basal Cell Skin Cancer.
Josep Malvehy practices in Barcelona, Spain. Mr. Malvehy is rated as an Elite expert by MediFind in the treatment of Actinic Keratosis. His top areas of expertise are Melanoma, Actinic Keratosis, Tieche-Jadassohn Nevus, Tissue Biopsy, and Lymphadenectomy.
A small number of these skin growths turn into squamous cell carcinoma.
Contact your provider if you see or feel a rough or scaly spot on your skin, or if you notice any other skin changes.
The best way to lower your risk for actinic keratosis and skin cancer is to learn how to protect your skin from sun and ultraviolet (UV) light.
Things you can do to lower your exposure to sunlight include:
- Wear clothing such as hats, long-sleeved shirts, long skirts, or pants.
- Try to avoid being in the sun during midday, when ultraviolet light is most intense.
- Use high-quality sunscreens, preferably with a sun protection factor (SPF) rating of at least 30. Pick a broad-spectrum sunscreen that blocks both UVA and UVB light.
- Apply sunscreen before going out into the sun, and reapply often -- at least every 2 hours while in the sun.
- Use sunscreen year-round, including in the winter.
- Avoid sun lamps, tanning beds, and tanning salons.
Other things to know about sun exposure:
- Sun exposure is stronger in or near surfaces that reflect light, such as water, sand, snow, concrete, and areas painted white.
- Sunlight is more intense at the beginning of the summer.
- Skin burns faster at higher altitudes.
Summary: The goal of this clinical research study is to compare the effects of topical fluorouracil alone to topical fluorouracil plus topical calcipotriene in patients with multiple actinic keratoses. Topical means the medication is applied directly to the skin.
Summary: The goal of this clinical trial is to show superiority of Veregen® 10% ointment to Placebo measured by complete (100%) clearance of a pre-defined treatment area (TA) following a treatment period of 12 weeks and a 4-weeks post-treatment (PT) period (i.e., after 16 weeks at most in patients without complete clearance at the end of the treatment (EoT) period).
Published Date: October 13, 2024
Published By: Ramin Fathi, MD, FAAD, Director, Phoenix Surgical Dermatology Group, Phoenix, AZ. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
American Academy of Dermatology Association website. Actinic keratosis: diagnosis and treatment. www.aad.org/public/diseases/skin-cancer/actinic-keratosis-treatment. Updated February 23, 2022. Accessed October 22, 2024.
Ball JW, Dains JE, Flynn JA, Solomon BS, Stewart RW. Skin, hair, and nails. In: Ball JW, Dains JE, Flynn JA, Solomon BS, Stewart RW, eds. Seidel's Guide to Physical Examination. 10th ed. St Louis, MO: Elsevier; 2023:chap 9.
Dinulos JGH. Premalignant and malignant nonmelanoma skin tumors. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 21.
Wolf IH, Soyer HP, McMeniman EK, Wolf P. Actinic keratosis, basal cell carcinoma, and squamous cell carcinoma. In: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatology. 5th ed. Philadelphia, PA: Elsevier; 2025:chap 108.