Actinic Keratosis Clinical Trials

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Patient and Clinician Reported Outcomes Among Patients With Actinic Keratosis Receiving Tirbanibulin for Large fiEld Application on the Face, in U.S Clinical pRactice Settings: A Pilot Initiative (CLEAR)

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY

The goal of this observational study is to learn about the effectiveness of tirbanibulin among adult subjects with actinic keratosis (AK) lesions in the face. The main question it aim to answer is: How does tirbanibulin improve subject's overall appearance of the skin, improve how patient's skin looks, and improve patient's skin texture, in a 57-day observation period. Participants already taking tirbanibulin as part of their regular medical care for AK will answer online survey questions at the beginning of the study and at Day 57.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Diagnosed with AK on the face.

• Has clinically typical, visible, and discrete 4-12 AK lesions on the face.

• Considered as a potential candidate for tirbanibulin (Klisyri®) treatment to manage their AK lesions on the face.

• Male or female, aged 18 years and above at the time of initiation of treatment with tirbanibulin.

• Willing to avoid excessive sun or UV exposure, and/or use relevant sunscreen protection and protective clothing during the study duration.

• Able to read and write in English.

• Provide consent to participate in the study.

• Willing to comply with all study procedures (including photography tasks) and be available for the duration of the study.

Locations
United States
California
Ablon Skin Institute and Research Center
RECRUITING
Manhattan Beach
South Carolina
Dermatology & Laser Center of Charleston
RECRUITING
Charleston
Contact Information
Primary
Siva Narayanan, PhD, MPhil, MHS, MSc
info@avant-health.com
301-799-AVANT
Time Frame
Start Date: 2026-04-02
Estimated Completion Date: 2026-10
Participants
Target number of participants: 30
Treatments
Tirbanibulin
Participants will receive tirbanibulin ointment 3.5 mg in 350 mg (as 1 single-dose packet per application, for 5 consecutive days). The participants will be observed for 57 days to gather participant reported outcomes (PROs) and clinical profile.
Related Therapeutic Areas
Sponsors
Leads: Avant Health LLC

This content was sourced from clinicaltrials.gov