Activated PI3K Delta Syndrome (APDS)Symptoms, Doctors, Treatments, Advances & More
Learn About Activated PI3K Delta Syndrome (APDS)
Activated PI3K-delta syndrome (also known as APDS) is a disorder that impairs the immune system. Individuals with this condition often have low numbers of white blood cells (lymphopenia), particularly B cells and T cells. Normally, these cells recognize and attack foreign invaders, such as viruses and bacteria, to prevent infection. The severity of activated PI3K-delta syndrome varies widely. Some people may have multiple, severe infections while others show mild symptoms to none at all.
Activated PI3K-delta syndrome is caused by variants (also called mutations) in the PIK3CD gene and the PIK3R1 gene. Activated PI3K-delta syndrome type 1 is caused by variants in the PIK3CD gene, which provides instructions for making a protein called p110 delta (p110δ). Activated PI3K-delta syndrome type 2 is caused by variants in the PIK3R1 gene. This gene provides instructions for making slightly different versions of another protein; the most common version is called p85 alpha (p85α).
Activated PI3K-delta syndrome is considered a rare disorder, but its exact prevalence is unknown.
Activated PI3K-delta syndrome is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
ASST Spedali Civili Di Brescia
Vassilios Lougaris practices practicing medicine in Brescia, Italy. Mr. Lougaris is rated as an Elite expert by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 12 other conditions, according to our data. His clinical expertise encompasses Selective Deficiency of IgA, Activated PI3K Delta Syndrome (APDS), Common Variable Immune Deficiency, Primary Immunodeficiency (PID), and Bone Marrow Transplant.
Herach Yadegarian, MD Private Practice
To provide the most complete care to my patients in a caring and respectful way. Dr. Yadegarian is rated as a Distinguished provider by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 13 other conditions, according to our data. His clinical expertise encompasses High Cholesterol, Activated PI3K Delta Syndrome (APDS), Holocarboxylase Synthetase Deficiency, and ZAP70-Related Severe Combined Immunodeficiency. Dr. Yadegarian is currently accepting new patients.
Reading Hospital Neurology Suite 210
Gabriel Pilar is a Neurologist practicing medicine in West Reading, Pennsylvania. Dr. Pilar is rated as an Advanced provider by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 26 other conditions, according to our data. His clinical expertise encompasses Activated PI3K Delta Syndrome (APDS), Guillain-Barre Syndrome, Miller-Fisher Syndrome, and Chronic Polyradiculoneuritis. Dr. Pilar is board certified in American Board Of Psychiatry And Neurology.
Published Date: August 16, 2023
Published By: National Institutes of Health