Activated PI3K Delta Syndrome (APDS)Symptoms, Doctors, Treatments, Advances & More
Learn About Activated PI3K Delta Syndrome (APDS)
Activated PI3K-delta syndrome (also known as APDS) is a disorder that impairs the immune system. Individuals with this condition often have low numbers of white blood cells (lymphopenia), particularly B cells and T cells. Normally, these cells recognize and attack foreign invaders, such as viruses and bacteria, to prevent infection. The severity of activated PI3K-delta syndrome varies widely. Some people may have multiple, severe infections while others show mild symptoms to none at all.
Activated PI3K-delta syndrome is caused by variants (also called mutations) in the PIK3CD gene and the PIK3R1 gene. Activated PI3K-delta syndrome type 1 is caused by variants in the PIK3CD gene, which provides instructions for making a protein called p110 delta (p110δ). Activated PI3K-delta syndrome type 2 is caused by variants in the PIK3R1 gene. This gene provides instructions for making slightly different versions of another protein; the most common version is called p85 alpha (p85α).
Activated PI3K-delta syndrome is considered a rare disorder, but its exact prevalence is unknown.
Activated PI3K-delta syndrome is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.
University Hospital Plastic Surgery Clinic
Venkat Rao is a Plastic Surgeon and a Hand Surgeon practicing medicine in Madison, Wisconsin. Dr. Rao is rated as an Elite provider by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 2 other conditions, according to our data. His clinical expertise encompasses Activated PI3K Delta Syndrome (APDS), Breast Enlargement In Males, Ganglion Cyst, Bone Marrow Aspiration, and Splenectomy. Dr. Rao is board certified in Plastic Surgery. Dr. Rao is currently accepting new patients.
ASST Spedali Civili Di Brescia
Vassilios Lougaris practices practicing medicine in Brescia, Italy. Mr. Lougaris is rated as an Elite expert by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 11 other conditions, according to our data. His clinical expertise encompasses Selective Deficiency of IgA, Activated PI3K Delta Syndrome (APDS), Common Variable Immune Deficiency, Primary Immunodeficiency (PID), and Bone Marrow Transplant.
Harbor Medical Clinic
Pavel Polskiy is a primary care provider, practicing in Family Medicine in West Sacramento, California. Dr. Polskiy is rated as a Distinguished provider by MediFind in the treatment of Activated PI3K Delta Syndrome (APDS). He is also highly rated in 31 other conditions, according to our data. His clinical expertise encompasses Holocarboxylase Synthetase Deficiency, ZAP70-Related Severe Combined Immunodeficiency, Activated PI3K Delta Syndrome (APDS), and Campylobacter Infection. Dr. Polskiy is board certified in Family Medicine. Dr. Polskiy is currently accepting new patients.
Published Date: August 16, 2023
Published By: National Institutes of Health