The Role of Cerebellum in Speech

Status: Active_not_recruiting
Location: See all (3) locations...
Intervention Type: Diagnostic test, Device, Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study will investigate the how the cerebellum is involved in speech motor learning over time and short-term corrections in patients with cerebellar ataxia and healthy controls. This will be accomplished through three approaches: behavioral studies, magnetic resonance imaging (MRI), and transcranial magnetic stimulation (TMS). During behavioral studies, participants will be asked to speak into a microphone while their voice is played back over earphones, and to do other speaking tasks. MRI will be acquired to perform a detailed analysis on brain function and anatomy related to speech and the cerebellum. In healthy controls, TMS will also be performed to temporarily disrupt the cerebellum before, during, or after the participant performs speaking tasks. Patients with cerebellar ataxia and healthy volunteers will be asked to complete behavioral studies and/or MRI; healthy volunteers may be asked to additionally participate in TMS.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

• Diagnosis of cerebellar ataxia (CA) resulting from degeneration of the cerebellum AND normal hearing abilities OR

• Healthy volunteers with no known history of physical or neurological abnormalities AND normal speech, hearing, and reading abilities

• For some studies, primary language of American English may be required

Locations
United States
California
University of California, Berkeley
Berkeley
University of California, San Francisco
San Francisco
Wisconsin
University of Wisconsin--Madison
Madison
Time Frame
Start Date: 2019-09-15
Completion Date: 2030-05-31
Participants
Target number of participants: 660
Treatments
Experimental: Patients with cerebellar ataxia (CA)
Behavioral testing including various speaking tasks Magnetic resonance imaging (MRI)
Active_comparator: Matched controls
Behavioral testing including various speaking tasks Magnetic resonance imaging (MRI)
Experimental: Additional healthy volunteers
Behavioral testing including various speaking tasks Magnetic resonance imaging (MRI) Transcranial magnetic stimulation (TMS)
Authors
Richard Ivry
Sponsors
Leads: University of California, San Francisco
Collaborators: National Institute on Deafness and Other Communication Disorders (NIDCD), University of California, Berkeley, University of Wisconsin, Madison

This content was sourced from clinicaltrials.gov