Comparison of High and Moderate Intensity Statins in Achieving the Target LDL-C Level After Acute Coronary Syndrome: Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study evaluates the effectiveness of high- and moderate-intensity statins in achieving target low-density lipoprotein cholesterol (LDL-C) levels in patients with acute coronary syndrome (ACS). The study aims to determine whether moderate-intensity statins can provide comparable benefits to high-intensity statins, particularly for patients at higher risk of adverse effects from higher doses. The findings may inform treatment decisions and reduce financial and clinical burdens on patients.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 85
Healthy Volunteers: f
View:
• Participants aged between 25 and 85 years.
• Both males and females.
• Diagnosed with acute coronary syndrome as defined in the operational definitions.
Locations
Other Locations
Pakistan
MTI-KTH (Medical Teaching Institution-Khyber Teaching Hospital), Peshawar-Pakistan
RECRUITING
Peshawar
Contact Information
Primary
Dr Shafeeq Mehmood, MBBS
shafeeqmehmood001@gmail.com
+92 315 9576362
Backup
Muhammad Faheem Khan, MBBS
drfaheem@live.com
92 333 9202002
Time Frame
Start Date: 2024-12-20
Estimated Completion Date: 2025-08-25
Participants
Target number of participants: 190
Treatments
Active_comparator: Moderate-Intensity Statin Group
Participants in this group will receive moderate-intensity statins (Atorvastatin 20 mg, Rosuvastatin 10 mg). The dosage will be in the tablet form, which will be Dosage Form: Tablet Frequency: Once daily Duration: 3 months
Active_comparator: High-Intensity Statin Group
Participants in this group will receive high-intensity statins. Interventions include Atorvastatin 40 mg, or Rosuvastatin 20 mg which will be taken in tablet form.~Frequency: Once daily Duration: 3 months
Related Therapeutic Areas
Sponsors
Collaborators: Khyber Teaching Hospital
Leads: Khyber Medical University Peshawar