Women With isoLated acUte cyStitis and Macroscopic Hematuria. Is Further Investigation Needed? A Prospective Multicenter Study. BLUSH Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Observational
SUMMARY
This prospective multicenter observational study evaluates whether women ≥50 years with isolated acute hemorrhagic cystitis (AHC) and macroscopic hematuria require full malignancy workup. All participants undergo standard diagnostics (cystoscopy, CT urography, cytology), with 12-month follow-up for cancer detection. The aim is to identify low-risk patients where invasive investigations may be safely avoided.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 110
Healthy Volunteers: t
View:
• Women ≥50 years of age.
• Macroscopic hematuria.
• Presenting for evaluation within the SCP for macroscopic hematuria.
• Ability to provide informed consent.
Locations
Other Locations
Sweden
Uddevalla Hospital
RECRUITING
Uddevalla
Contact Information
Primary
Suleiman Abuhasanein, PhD
suleiman.abuhasanein@gu.se
0104353572
Time Frame
Start Date: 2025-10-13
Estimated Completion Date: 2027-08-30
Participants
Target number of participants: 300
Treatments
AHG (Acute Hemorrhagic Cystitis Group):
Patients with acute onset macroscopic hematuria with lower urinary tract symptoms such as dysuria, frequency, and urgency of less than one week's duration.
non AHG (non-Acute Hemorrhagic Cystitis Group):
Patients with atypical clinical presentation such as:~Chronic irritative symptoms \>4 weeks. Recurrent UTI (≥2 episodes in 6 months or ≥3 episodes per year). Febrile UTI. Absence of irritative symptoms.
Related Therapeutic Areas
Sponsors
Leads: Vastra Gotaland Region