Acute Hepatic Porphyria (AHP) Overview

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Learn About Acute Hepatic Porphyria (AHP)

What is the definition of Acute Hepatic Porphyria (AHP)?
Acute hepatic porphyria is a genetic metabolic disorder caused by a defect in the enzyme that assists heme synthesis, which results in the accumulation of porphyrins. Heme is involved in the production of hemoglobin, or the oxygen-carrying element in the blood, and porphyrins are molecules that help produce heme. There are several types of hepatic porphyria, including acute intermittent porphyria, variegate porphyria, aminolevulinic acid dehydratase deficiency porphyria, hereditary coproporphyria, and porphyria cutanea tarda.
What are the symptoms of Acute Hepatic Porphyria (AHP)?
Symptoms of acute hepatic porphyria may include severe abdominal, chest, arm, leg, and back pain; nausea; vomiting; constipation; rapid heartbeat; high blood pressure; muscle weakness; sensory loss; multiple nerve pain; blistering rashes; excessive hair loss; dark or reddish-brown urine; low blood sodium levels; seizures; and psychosis.
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What are the current treatments for Acute Hepatic Porphyria (AHP)?
Treatment for acute hepatic porphyria includes the administration of pain medication and intravenous hemin; carbohydrate loading; intravenous hypertonic saline; seizure control with benzodiazepine, gabapentin, Propofol, or magnesium; and liver transplantation.
Who are the top Acute Hepatic Porphyria (AHP) Local Doctors?
Elite in Acute Hepatic Porphyria (AHP)
Dr. Karl Anderson
Gastroenterology
Elite in Acute Hepatic Porphyria (AHP)
Dr. Karl Anderson
Gastroenterology

Utmb Faculty Group Practice

301 University Blvd, 
Galveston, TX 
409-772-2222
Languages Spoken:
English
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Karl Anderson is a Gastroenterologist in Galveston, Texas. Dr. Anderson is rated as an Elite provider by MediFind in the treatment of Acute Hepatic Porphyria (AHP). His top areas of expertise are Porphyria, Acute Hepatic Porphyria (AHP), Hepatitis C, and Hepatitis.

Elite in Acute Hepatic Porphyria (AHP)
Paolo Ventura
Elite in Acute Hepatic Porphyria (AHP)
Paolo Ventura
Modena, IT 

Paolo Ventura practices in Modena, Italy. Mr. Ventura is rated as an Elite expert by MediFind in the treatment of Acute Hepatic Porphyria (AHP). His top areas of expertise are Acute Hepatic Porphyria (AHP), Porphyria, Acute Intermittent Porphyria, and Variegate Porphyria.

 
 
 
 
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Elite in Acute Hepatic Porphyria (AHP)
Ulrich Stolzel
Elite in Acute Hepatic Porphyria (AHP)
Ulrich Stolzel
Chemnitz, SN, DE 

Ulrich Stolzel practices in Chemnitz, Germany. Mr. Stolzel is rated as an Elite expert by MediFind in the treatment of Acute Hepatic Porphyria (AHP). His top areas of expertise are Acute Hepatic Porphyria (AHP), Porphyria, Acute Intermittent Porphyria, Hereditary Coproporphyria, and Liver Transplant.

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What are the latest Acute Hepatic Porphyria (AHP) Clinical Trials?
ELEVATE, a Global Observational Longitudinal Prospective Registry of Patients With Acute Hepatic Porphyria (AHP)
ELEVATE, a Global Observational Longitudinal Prospective Registry of Patients With Acute Hepatic Porphyria (AHP)
Enrollment Status: Recruiting
Publish Date: September 19, 2025

Summary: This global patient registry is being conducted to characterize the natural history and real-world clinical management of patients with AHP, and to further characterize the real-world safety and effectiveness of givosiran and other approved AHP therapies.

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