Acute Hepatic Porphyria Symptoms, Doctors, Treatments, Advances & More

Learn About Acute Hepatic Porphyria

What is the definition of Acute Hepatic Porphyria?

Acute hepatic porphyria is a genetic metabolic disorder caused by a defect in the enzyme that assists heme synthesis, which results in the accumulation of porphyrins. Heme is involved in the production of hemoglobin, or the oxygen-carrying element in the blood, and porphyrins are molecules that help produce heme. There are several types of hepatic porphyria, including acute intermittent porphyria, variegate porphyria, aminolevulinic acid dehydratase deficiency porphyria, hereditary coproporphyria, and porphyria cutanea tarda.

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What are the symptoms of Acute Hepatic Porphyria?

Symptoms of acute hepatic porphyria may include severe abdominal, chest, arm, leg, and back pain; nausea; vomiting; constipation; rapid heartbeat; high blood pressure; muscle weakness; sensory loss; multiple nerve pain; blistering rashes; excessive hair loss; dark or reddish-brown urine; low blood sodium levels; seizures; and psychosis.

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What are the current treatments for Acute Hepatic Porphyria?

Treatment for acute hepatic porphyria includes the administration of pain medication and intravenous hemin; carbohydrate loading; intravenous hypertonic saline; seizure control with benzodiazepine, gabapentin, Propofol, or magnesium; and liver transplantation.

Who are the top Acute Hepatic Porphyria Local Doctors?

Eliane Sardh

Elite

Highly rated in

conditions

Karolinska University Hospital

Department Of Medicine

Huddinge, AB, SE

Eliane Sardh is in Huddinge, Sweden. Sardh is rated as an Elite expert by MediFind in the treatment of Acute Hepatic Porphyria. She is also highly rated in 5 other conditions, according to our data. Her top areas of expertise are Acute Hepatic Porphyria, Porphyria, Acute Intermittent Porphyria, and Hereditary Coproporphyria.

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Ulrich Stolzel

Elite

Highly rated in

conditions

Klinikum Chemnitz

Chemnitz, SN, DE

Ulrich Stolzel is in Chemnitz, Germany. Stolzel is rated as an Elite expert by MediFind in the treatment of Acute Hepatic Porphyria. He is also highly rated in 8 other conditions, according to our data. His top areas of expertise are Acute Hepatic Porphyria, Hereditary Coproporphyria, Porphyria, and Acute Intermittent Porphyria.

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Pauline S. Harper

Elite

Highly rated in

conditions

Karolinska University Hospital

Stockholm, AB, SE

Pauline Harper is in Stockholm, Sweden. Harper is rated as an Elite expert by MediFind in the treatment of Acute Hepatic Porphyria. She is also highly rated in 8 other conditions, according to our data. Her top areas of expertise are Acute Hepatic Porphyria, Porphyria, Acute Intermittent Porphyria, and Variegate Porphyria.

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What are the latest Acute Hepatic Porphyria Clinical Trials?

Prevalence of Acute Hepatic Porphyria in Population With Suggestive Clinical Picture

Status: Not yet recruiting

Start Date: June 2021

Intervention Type: Other

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Summary: To determine the proportion of patients suffering from acute hepatic porphyria (AHP) from different hospital departments and referred to an internist referent for a suggestive clinical picture with a first negative etiological assessment.

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Longitudinal Study of the Porphyrias

Status: Recruiting

Start Date: November 1, 2010

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Summary: The objective of this protocol is to conduct a longitudinal multidisciplinary investigation of the human porphyrias including the natural history, morbidity, pregnancy outcomes, and mortality in people with these disorders.

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What are the Latest Advances for Acute Hepatic Porphyria?