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Learn About Acute Intermittent Porphyria

What is the definition of Acute Intermittent Porphyria?
Acute intermittent porphyria (AIP) is one of the liver (hepatic) porphyrias. AIP is caused by low levels of porphobilinogen deaminase (PBGD), an enzyme also often called hydroxymethylbilane synthase. The low levels of PBGD are generally not sufficient to cause symptoms; however, activating factors such as hormones, drugs, and dietary changes may trigger symptoms. Although most individuals with AIP never develop symptoms, symptomatic individuals typically present with abdominal pain with nausea.
What are the alternative names for Acute Intermittent Porphyria?
  • Acute intermittent porphyria
  • AIP
  • HMBS deficiency
  • Hydroxymethylbilane synthase deficiency
  • PBGD deficiency
  • Porphobilinogen deaminase deficiency
  • Porphyria, Swedish type
  • UPS deficiency
  • Uroporphyrinogen synthase deficiency
Who are the top Acute Intermittent Porphyria Local Doctors?
Elite in Acute Intermittent Porphyria
Elite in Acute Intermittent Porphyria

Karolinska Institutet

Stockholm, AB, SE 

Eliane Sardh practices in Stockholm, Sweden. Ms. Sardh is rated as an Elite expert by MediFind in the treatment of Acute Intermittent Porphyria. Her top areas of expertise are Acute Hepatic Porphyria (AHP), Acute Intermittent Porphyria, Porphyria, and Variegate Porphyria.

Elite in Acute Intermittent Porphyria
Elite in Acute Intermittent Porphyria

Karolinska Institutet

Stockholm, AB, SE 

Pauline Harper practices in Stockholm, Sweden. Ms. Harper is rated as an Elite expert by MediFind in the treatment of Acute Intermittent Porphyria. Her top areas of expertise are Acute Intermittent Porphyria, Porphyria, Acute Hepatic Porphyria (AHP), and Variegate Porphyria.

 
 
 
 
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Elite in Acute Intermittent Porphyria
Elite in Acute Intermittent Porphyria
Pamplona, NC, ES 

Antonio Fontanellas practices in Pamplona, Spain. Mr. Fontanellas is rated as an Elite expert by MediFind in the treatment of Acute Intermittent Porphyria. His top areas of expertise are Acute Intermittent Porphyria, Porphyria, Urea Cycle Disorders (UCD), and Inborn Amino Acid Metabolism Disorder.

What are the latest Acute Intermittent Porphyria Clinical Trials?
Identification of Acute Intermittent Porphyria Modifying Genes

Summary: This study proposes to identify the predisposing/protective modifying genes that underlie the acute attacks in symptomatic patients with Acute Intermittent Porphyria (AIP), an autosomal dominant inborn error of heme biosynthesis.

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Clinical Research on Acute Intermittent Porphyria and the Use of Carbohydrate-Rich Diet as a Treatment

Summary: The main aim of this clinical trial is to learn about the effect of carbohydrate-rich diet as a treatment for AIP (acute intermittent porphyria). Aim: Investigate the diet's impact on tissue and serum glucose, plasma insulin, cytokine levels, amino acids, and gut microbiota in AIP, and their correlation with PBG (Porphobilinogen). Aim: Assess the diet's effect on AIP symptoms and health status in ...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center