Investigation of the Effects of Standard Rehabilitation Program and Inspiratory Muscle Training on lncRNA HOTAIR Expression in Patients With Rheumatoid Arthritis

Status: Recruiting
Location: See location...
Intervention Type: Behavioral, Other, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this observational study is to examine the effects of traditional respiratory rehabilitation and respiratory muscle strengthening training added to this program at the genetic level in in patients with rheumatoid arthritis-associated interstitial lung disease. The main questions it aims to answer are: * Does respiratory muscle strengthening exercise added to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have additional benefits on rehabilitation outcome measures such as exercise capacity, shortness of breath, and muscle strength? * Does the gain obtained with respiratory muscle strengthening iin patients with rheumatoid arthritis-associated interstitial lung disease increase the quality of life of patients and have a positive effect on their psychological state? * Does respiratory rehabilitation applied to iin patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Does respiratory muscle strengthening training applied in addition to respiratory rehabilitation in patients with rheumatoid arthritis-associated interstitial lung disease have an effect on genetic changes? * Participants will be included in two different respiratory rehabilitation programs with and without respiratory muscle training, and pre- and post- treatment rehabilitation criteria and genetic changes will be compared.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: t
View:

• Diagnosed with RA according to the ACR/EULAR 2010 classification criteria

• Duration of diagnosis greater than 2 years

• Disease activity with a DAS28 score below 5.1

• Voluntary participation in the study

• Presence of lung involvement

Locations
Other Locations
Turkey
University of Health Sciences
RECRUITING
Istanbul
Contact Information
Primary
Zeynep Betül ÖZCAN
zbetulozcan@gmail.com
+90 216 346 36 36
Backup
Esra PEHLİVAN
esra.pehlivan@sbu.edu.tr
+90 216 346 36 36
Time Frame
Start Date: 2024-05-18
Estimated Completion Date: 2026-03-12
Participants
Target number of participants: 39
Treatments
Active_comparator: Standart Pulmonary Rehabilitation Group (SGr)
In the SGr program, exercises are planned to be performed under the supervision of a remote physiotherapist, 2 days a week with the telerehabilitation method and 1 day as a home- based program by the patient. The exercise program includes aerobic, resistance exercises and respiratory exercises, and patients are followed for 3 months.
Experimental: Pulmonary Rehabilitation Group with Inspiratory Muscle Training (IGr)
In the IGr program, exercises are planned under the supervision of a remote physiotherapist, with the telerehabilitation method 2 days a week and with a program to be done by the patient at home 1 day a week. The exercise program includes aerobics, resistance exercises, respiratory exercises and respiratory muscle strengthening training with a resistive thereshold inspiratory muscle strengthening device, and patients are followed for 3 months.
Other: Control Group (CGr)
The KGr group will consist of women and men aged between 18-75, who have signed the informed consent form regarding the study, have a BMI \<30, are non-smokers, have no known systemic disease, and have FEV1\>80, and are age and gender matched to the exercise groups.
Sponsors
Leads: Saglik Bilimleri Universitesi

This content was sourced from clinicaltrials.gov