TAA05 Cell Injection in the Treatment of Recurrent / Refractory Acute Myeloid Leukemia
This is a clinical study of ytaa05 cell injection in the treatment of patients with recurrent / refractory acute myeloid leukemia.The purpose is to evaluate the safety and preliminary efficacy of FLT3 car-t cells in patients with recurrent / refractory FLT3 positive acute myeloid leukemia.#TAA05 cell injection is a T cell targeting FLT3 chimeric antigen receptor#
⁃ Age 18 \
• 70 years old (including boundary value), regardless of gender;
⁃ Acute myeloid leukemia with FLT3 positive (positive rate ≥ 30%) verified by flow cytometry or immunohistochemistry;
⁃ The expected survival time was more than 12 weeks;
⁃ ECoG score 0-2;
⁃ Refractory or relapse after standardized treatment;
⁃ Liver and kidney function and cardiopulmonary function meet the following requirements:
∙ Creatinine ≤ 1.5 ULN;
‣ Left ventricular ejection fraction ≥ 45%;
‣ Blood oxygen saturation \> 91%;
‣ Total bilirubin ≤ 1.5 × ULN; ALT and AST ≤ 2.5 × ULN;
⁃ Understand the test and have signed the informed consent form.