TAA05 Cell Injection in the Treatment of Recurrent / Refractory Acute Myeloid Leukemia

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This is a clinical study of ytaa05 cell injection in the treatment of patients with recurrent / refractory acute myeloid leukemia.The purpose is to evaluate the safety and preliminary efficacy of FLT3 car-t cells in patients with recurrent / refractory FLT3 positive acute myeloid leukemia.#TAA05 cell injection is a T cell targeting FLT3 chimeric antigen receptor#

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:

⁃ Age 18 \

• 70 years old (including boundary value), regardless of gender;

⁃ Acute myeloid leukemia with FLT3 positive (positive rate ≥ 30%) verified by flow cytometry or immunohistochemistry;

⁃ The expected survival time was more than 12 weeks;

⁃ ECoG score 0-2;

⁃ Refractory or relapse after standardized treatment;

⁃ Liver and kidney function and cardiopulmonary function meet the following requirements:

∙ Creatinine ≤ 1.5 ULN;

‣ Left ventricular ejection fraction ≥ 45%;

‣ Blood oxygen saturation \> 91%;

‣ Total bilirubin ≤ 1.5 × ULN; ALT and AST ≤ 2.5 × ULN;

⁃ Understand the test and have signed the informed consent form.

Locations
Other Locations
China
Anhui Provincial Hospital
RECRUITING
Hefei
Contact Information
Primary
Xingbing Wang
wangxingbing@ustc.edu.cn
13856007984
Backup
Huimin Meng
huimin.meng@persongen.com.cn
0551-65728070
Time Frame
Start Date: 2021-07-01
Estimated Completion Date: 2025-10
Participants
Target number of participants: 5
Treatments
Experimental: TAA05 cell injection
TAA6 cell injection#Targeting FLT3 autologous chimeric antigen receptor T cells#
Related Therapeutic Areas
Sponsors
Collaborators: Anhui Provincial Hospital
Leads: PersonGen BioTherapeutics (Suzhou) Co., Ltd.

This content was sourced from clinicaltrials.gov