Epidemiological Study of a Prospective Cohort of Patients Aged 60 and Over Managed for Acute Myeloid Leukemia (AML) and Receiving Intensive Induction Therapy

Status: Recruiting
Location: See all (27) locations...
Study Type: Observational
SUMMARY

This observational epidemiological study targets patients aged 60 and over with de novo or secondary acute myeloblastic leukemia suitable for intensive receive intensive induction therapy as defined by the group. The main aim of the study is to determine the epidemiological characteristics of AML patients, both clinically and biologically, and to correlate these to their outcome. The incidence of AML increases with age, exponentially after the age of 50, giving a median age at diagnosis of close to 70 years, with over half of patients half of patients are over 60 at diagnosis. The principle of treatment as in younger patients, is based on trying to achieve complete remission (CR). remission (CR). Observed complete remission rates range from 38 to 70%. Long-term survival of elderly subjects remains limited, at around 10 to 15%, despite the various types of consolidation tried out in recent years. years. However, intensive chemotherapy remains the preferred option for initial treatment of these hematological diseases when general condition and comorbidities allow. As shown by Swedish registry studies, it is associated with improved life expectancy. The proportion of patients who can receive intensive initial treatment is not well known in France, probably varies widely from one region to another, and certainly decreases with increasing age. Only the registry studies currently underway will enable us to assess this precisely.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• Patients aged 60 and over

• Patients with previously untreated de novo or secondary AML

• Patients suitable for standard intensive treatment

• Patients who have read the information document and agreed to the collection of data concerning them (signature of informed consent).

Locations
Other Locations
France
Angers CHU
RECRUITING
Angers
Annecy CH
RECRUITING
Annecy
Avignon CH
RECRUITING
Avignon
Bayonne CH
RECRUITING
Bayonne
Besançon CHU
RECRUITING
Besançon
Brest CHU
RECRUITING
Brest
CHU Estaing
RECRUITING
Clermont-ferrand
Colmar CH
RECRUITING
Colmar
Grenoble CHU
RECRUITING
Grenoble
Marseille IPC
RECRUITING
Marseille
METZ-THIONVILLE CHR- Hôpital de Mercy
RECRUITING
Metz
Montpellier - Chu Saint Eloi
RECRUITING
Montpellier
Mulhouse Chu
RECRUITING
Mulhouse
Nantes CHU
RECRUITING
Nantes
Nimes CHU
RECRUITING
Nîmes
Orléans CHU
RECRUITING
Orléans
Paris Cochin, APHP
RECRUITING
Paris
Perpignan CH
RECRUITING
Perpignan
Bordeaux CHU
RECRUITING
Pessac
Poitiers CHU
RECRUITING
Poitiers
Reims CHU
RECRUITING
Reims
Rennes CHU
RECRUITING
Rennes
CHU de Saint-Etienne
RECRUITING
Saint-priest-en-jarez
ICANS - Institut de cancérologie de strasbourg europe
RECRUITING
Strasbourg
Toulouse - IUCT Oncopole - Service d'Hématologie
RECRUITING
Toulouse
Tours CHU
RECRUITING
Tours
Nancy CHU
RECRUITING
Vandœuvre-lès-nancy
Contact Information
Primary
Ariane Mineur
ariane.mineur@chu-bordeaux.fr
+33 (5)57 62 31 08
Time Frame
Start Date: 2015-01-06
Estimated Completion Date: 2031-01-06
Participants
Target number of participants: 1000
Related Therapeutic Areas
Sponsors
Leads: French Innovative Leukemia Organisation

This content was sourced from clinicaltrials.gov

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