• Understand the research and sign a written informed consent form;

• Be newly diagnosed with AML according to WHO 2022 criteria without prior treatment;

• or unwilling to undergo IC. Ineligibility for IC is defined as meeting any of the following criteria:

• Age ≥ 60 years

• Age 18-59 years but ineligible for intensive chemotherapy (IC) , meet ≥1 of the following:

‣ Eastern Cooperative Oncology Group (ECOG) performance status ≥2 at screening;

⁃ Severe heart failure (congestive heart failure requiring treatment or myocardial infarction history with ejection fraction ≤50%);

⁃ Severe pulmonary dysfunction (DLCO ≤65%, FEV1 ≤65%, dyspnea at rest, or oxygen dependence);

⁃ Severe renal insufficiency requiring dialysis;

⁃ Child-Pugh B or C cirrhosis, or hepatic impairment with total bilirubin \>1.5×ULN;

• Mental illness requiring inpatient psychiatric treatment;

• Any comorbidity deemed by physician to contraindicate IC.