Collection of Biological Samples for Research Purposes: Determination of Epigenetic Markers of Acute Myeloblastic Leukemia in Elderly Patients
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Diagnostic test
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The main objective of this study is to identify epigenetic markers specific to abnormal myeloid cells in patients with acute myeloid leukemia (AML) by analyzing the methylation of circulating cell-free DNA in plasma.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: t
View:
⁃ Age ≥ 60 years;
⁃ Scheduled for cardiac surgery involving sternotomy;
⁃ Normal blood count within the two months preceding sampling;
⁃ Affiliated with, or beneficiary of, a social security system;
⁃ Written informed consent to participate in the study.
• Age ≥ 60 years;
• Diagnosis of de novo AML or AML secondary to myelodysplastic syndrome, scheduled to receive azacitidine-based treatment;
• Affiliated with, or beneficiary of, a social security system;
• Written informed consent to participate in the study.
Locations
Other Locations
France
GHRMSA
RECRUITING
Mulhouse
Groupe Hospitalier de la Région de Mulhouse et Sud Alsace
RECRUITING
Mulhouse
Contact Information
Primary
Bernard DRENOU, Dr
drenoub@ghrmsa.fr
+33389646464
Time Frame
Start Date: 2026-01-13
Estimated Completion Date: 2027-12-01
Participants
Target number of participants: 30
Treatments
Other: AML
Elderly patients diagnosed with acute myeloid leukemia. An additional volume of blood (10 mL) and bone marrow (2 mL) will be collected during follow-up visits as part of their routine care.
Other: Control group
Elderly patients scheduled for thoracic surgery involving sternotomy. A bone marrow sample (2 mL) will be obtained by sternal puncture in the operating room (after general anesthesia and before sternotomy), and an additional blood sample (10 mL) will be collected during the hospital stay.
Related Therapeutic Areas
Sponsors
Collaborators: Institut de Recherche en Hématologie et Transplantation (IRHT)
Leads: Groupe Hospitalier de la Region de Mulhouse et Sud Alsace