A Phase II, Multicenter, Open Label Study Evaluating the Efficacy and the Tolerance of Micro-transplantation in Elderly Patients With Acute Myeloid Leukemia (MTSA)
Who is this study for? Older adult patients with Acute Myeloid Leukemia
What treatments are being studied? HLA-Mismatched Microtransplant
Status: Recruiting
Location: See all (7) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims at evaluating the safety and the tolerance of the micro-transplantation in elderly patients with acute myeloid leukemia who are ineligible to conventional allogeneic transplantation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Maximum Age: 75
Healthy Volunteers: f
View:
• Patient affiliated to a social security regimen or beneficiary of the same
• Signed written informed consent form
• Patient, ≥ 60 years-old - \< 75 years-old, with established diagnosis of de novo or secondary AML with intermediate-risk or adverse-risk cytogenetic profile, or with established myelodysplasic syndromes (RAEB), in pathologically confirmed complete remission following anti-leukemic induction therapy (\<5% blasts)
• Contra-indication to conditioning regimen in conventional allogeneic transplantation
Locations
Other Locations
France
CHU Estaing
RECRUITING
Clermont-ferrand
Centre Hospitalier Universitaire de Grenoble
RECRUITING
Grenoble
CHRU de Lille
NOT_YET_RECRUITING
Lille
Centre Hospitalier Lyon Sud
RECRUITING
Lyon
Centre Hospitalier Universitaire de Nancy
NOT_YET_RECRUITING
Nancy
Hôpital de la Pitié-Salpêtrière
NOT_YET_RECRUITING
Paris
CHU de Saint-Etienne
RECRUITING
Saint-etienne
Contact Information
Primary
Jérôme Cornillon, MD
jerome.cornillon@chu-st-etienne.fr
04 77 91 67 26
Backup
Elisabeth Daguenet, PhD
elisabeth.daguenet@chu-st-etienne.fr
04 77 91 70 89
Time Frame
Start Date: 2019-01-08
Estimated Completion Date: 2027-12-31
Participants
Target number of participants: 21
Treatments
Experimental: HLA-mismatched micro-transplantation
HLA-mismatched micro-transplantation
Related Therapeutic Areas
Sponsors
Collaborators: Institut de Cancérologie de la Loire
Leads: Centre Hospitalier Universitaire de Saint Etienne