Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus
Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 8
Maximum Age: 35
Healthy Volunteers: t
View:
⁃ CXL Group
• Age 8-35 years
• Clinical diagnosis of keratoconus and seeking CXL treatment
• English speaking ability sufficient to comprehend consent with parental assistance
• MRI compatible
• Ability to lie still for an MRI session (60 minutes)
⁃ Control Group
• Age 8-35 years
• No diagnosis of keratoconus
• English speaking ability sufficient to comprehend consent with parental assistance
• MRI compatible
• Ability to lie still for an MRI session (60 minutes)
Locations
United States
Massachusetts
Boston Children's Hospital
RECRUITING
Boston
Contact Information
Primary
Eric A Moulton, OD PhD
eric.moulton@childrens.harvard.edu
617-919-6827
Backup
Nicholas J Pondelis, BA
nicholas.pondelis@childrens.harvard.edu
617-919-1895
Time Frame
Start Date: 2021-10-04
Estimated Completion Date: 2025-12
Participants
Target number of participants: 60
Treatments
CXL group
Patients who are about to undergo a corneal cross-linking (CXL) surgery to treat keratoconus.
Control group
Healthy volunteers age and sex matched to the CXL group.
Related Therapeutic Areas
Sponsors
Leads: Boston Children's Hospital