Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN)

Who is this study for? Patients with Postoperative Pain, Breast Cancer
What treatments are being studied? Lidocaine 
Status: Recruiting
Location: See all (16) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

Phase III, international multicentre, parallel group, blinded, 1:1 randomized controlled trial to determine the effect of an intraoperative intravenous lidocaine infusion on reducing the development of persistent pain 3-months after breast cancer surgery.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:

• Age ≥18 years old

• Undergoing a unilateral or bilateral lumpectomy or mastectomy, inclusive of all pathologies, including prophylactic surgery (e.g., family history or BRCA gene mutation)

Locations
Other Locations
Canada
Foothills Medical Centre
RECRUITING
Calgary
Sturgeon Community Hospital
RECRUITING
Edmonton
IWK
RECRUITING
Halifax
Juravinski Hospital
RECRUITING
Hamilton
Hôpital Maisonneuve-Rosemont
RECRUITING
Montreal
North York General Hospital
RECRUITING
North York
The Ottawa Hospital
RECRUITING
Ottawa
Eastern Health- Health Sciences Centre
RECRUITING
St. John's
Thunder Bay Regional Health Sciences Centre
RECRUITING
Thunder Bay
Humber River Hospital
RECRUITING
Toronto
Mount Sinai Hospital
RECRUITING
Toronto
St. Michael's Hospital
RECRUITING
Toronto
Sunnybrook Health Sciences Centre
RECRUITING
Toronto
University Health Network
RECRUITING
Toronto
Women's College Hospital
RECRUITING
Toronto
Nigeria
Obafemi Awolowo University Teaching Hospitals Complex
RECRUITING
Ile-ife
Contact Information
Primary
James Khan
James.Khan@medportal.ca
416-340-4800
Backup
Nour Ayach
Nour.Ayach@uhn.ca
416-340-4800
Time Frame
Start Date: 2021-09-22
Estimated Completion Date: 2026-06-01
Participants
Target number of participants: 1602
Treatments
Experimental: Intervention
Intraoperative intravenous lidocaine/placebo infusion
Placebo_comparator: Control
Intraoperative intravenous lidocaine/placebo infusion
Related Therapeutic Areas
Chronic Pain
Breast Cancer
Acute Pain
Sponsors
Collaborators: Canadian Institutes of Health Research (CIHR)
Leads: University Health Network, Toronto

This content was sourced from clinicaltrials.gov

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