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Efficacy of Ultrasound-Guided Retrolaminar Block Combined With Standard Multimodal Analgesia for Postoperative Pain Management in Lumbar Spine Surgery: A Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Other, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This randomized controlled trial evaluates the effectiveness of ultrasound-guided retrolaminar nerve block in addition to standard multimodal analgesia for postoperative pain management in patients undergoing lumbar spine surgery. Fifty patients will be randomly assigned to receive either the retrolaminar block combined with standard pain management or standard pain management alone. The primary outcome is total opioid consumption in the first 24 hours after surgery. Secondary outcomes include pain intensity at multiple time points, time to first rescue analgesia, duration of sensory block, incidence of postoperative nausea and vomiting, length of hospital stay, patient satisfaction, and chronic pain development at 3 and 6 months follow-up.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Adult patients aged 18-80 years

• Scheduled for elective lumbar spine surgery (with instrumentation)

• American Society of Anesthesiologists (ASA) physical status I-III

• Willing and able to provide written informed consent

• Able to use patient-controlled analgesia (PCA) device

Locations
Other Locations
Chile
Clínica Universidad de los Andes, Chile
RECRUITING
Santiago
Contact Information
Primary
Roberto Coloma, MD
rcoloma@clinicauandes.cl
(56) 22 618 3100
Backup
Nicolás Valls, MD, PhD
nvalls@clinicauandes.cl
+56 9 33741332
Time Frame
Start Date: 2026-03-01
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 50
Treatments
Experimental: Retrolaminar Block & Standard Analgesia
Patients receive bilateral ultrasound-guided retrolaminar blocks with Bupivacaine 0.25% and Epinephrine 50mcg (15 ml total volume per side) before surgery, along with standard multimodal analgesia.
Active_comparator: Standard Analgesia Only
Patients receive standard multimodal analgesia without regional anesthesia block.
Related Therapeutic Areas
Sponsors
Leads: Universidad de los Andes, Chile

This content was sourced from clinicaltrials.gov