Incidence of Reverse Trigger Phenotypes and Response to Ventilatory Adjustments in Patients With ARDS

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this prospective observational study is to describe the incidence of reverse trigger (RT) in mechanically ventilated patients with diagnosis of acute respiratory distress syndrome (ARDS). The main questions it aims to answer are: * Real incidence of RT based on continuous monitoring * The response to mechanical ventilatiory adjustments Participants will be included as soon as neuromuscular blockers (NMB)/sedation is stopped or in case of spontaneous respiratory efforts detection, whatever happens first. Continuous monitoring will be performed by esophageal manometry until switch to a pressure support (spontaneous) mode, restart of deep sedation/neuromuscular blockers by medical indication, or death. In order to allow detection of possible RT in patients with ongoing sedation/NMB, mechanical ventilator waveforms will be screened every 1-2 hours by investigators and critical care physicians with at least 1 year of specific training in detection of dyssynchronies.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 90
Healthy Volunteers: f
View:

• Diagnosis of ARDS according to the Berlin criteria and added New Global Definition 2023

• Mechanical ventilation

Locations
Other Locations
Mexico
Hospital Civil Fray Antonio Alcalde
RECRUITING
Guadalajara
Contact Information
Primary
Miguel Ibarra-Estrada, MD
drmiguelibarra@hotmail.com
+523317593502
Time Frame
Start Date: 2023-11-17
Estimated Completion Date: 2026-02-01
Participants
Target number of participants: 130
Sponsors
Leads: Hospital Civil de Guadalajara

This content was sourced from clinicaltrials.gov