Prospective, Retrospective, Multicenter, Observational Study of Disease Progression in Adults With Inherited Forms of Spastic Paraplegia
Status: Terminated
Location: See all (6) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
The course of AMN-related disabilities over time is poorly or incompletely understood due to a limited number of patients and lack of treatments. This study will help obtain a better understanding of the progression of disease with AMN and facilitate efficient clinical development of future interventional medications.
Eligibility
Participation Requirements
Sex: Male
Minimum Age: 18
Healthy Volunteers: f
View:
• Male adults aged ≥18 years
• Diagnosed with ALD based on elevated VLCFA assay and pedigree analysis
• Clinical evidence of spinal cord involvement with EDSS score between 1 and 6.5
Locations
United States
California
Stanford Neuroscience Health Center
Stanford
Massachusetts
Massachusetts General Hospital
Boston
New York
Weill Medical College of Cornell University
New York
Utah
University of Utah
Salt Lake City
Other Locations
Germany
University of Leipzig Medical Center
Leipzig
Netherlands
Amsterdam UMC
Amsterdam
Time Frame
Start Date: 2021-06-21
Completion Date: 2025-05-16
Participants
Target number of participants: 65
Treatments
Males with AMN
Adult males with confirmed diagnosis of ALD and symptoms of AMN.
Related Therapeutic Areas
Sponsors
Leads: SwanBio Therapeutics, Inc.