• Recurrent or advanced solid tumor and has disease

• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

• Participants in DES must have at least one non-target lesion as defined by RECIST version 1.1. Participants in Backfill Cohorts and EXP must have at least one measurable disease (target) lesion as defined by RECIST version 1.1.

• Tumor tissue, either archival or from a fresh tumor biopsy, available for testing or be willing to undergo a minimally invasive tumor biopsy to obtain tumor tissue for local testing, if not medically contraindicated, prior to Cycle 1 Day 1

• Brain magnetic resonance imaging (MRI) during the Screening period unless obtained within 30 days prior to Screening (based on standard clinical care), if they meet either of the following criteria:

‣ All participants with TNBC

⁃ Participants with a history of brain metastases or with neurologic symptoms or signs suspicious for brain metastases.