Learn About Adenoid Cystic Carcinoma

What is the definition of Adenoid Cystic Carcinoma?
Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, a type of cancer that begins in glandular tissues. It most commonly arises in the major and minor salivary glands of the head and neck. It can also occur in the breast, uterus, or other locations in the body. Symptoms depend on the tumor's location. Salivary gland tumors may cause painless masses in the mouth or face. Tumors of the lacrimal gland may cause a bulging eye or changes in vision. Those affecting the windpipe or voice box may cause respiratory symptoms or changes in speech, respectively. Advanced tumors may cause pain and/or nerve paralysis, as ACC often spreads along the nerves. It may also spread through the bloodstream. It spreads to the lymph nodes in about 5% to 10% of cases. The cause of ACC is currently unknown. It typically does not run in families.
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What are the alternative names for Adenoid Cystic Carcinoma?
  • Adenoid cystic carcinoma
  • Adenocystic carcinoma
  • Cribriform carcinoma
  • Cylindroma
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What are the latest Adenoid Cystic Carcinoma Clinical Trials?
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

Summary: This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for the following cohorts based on condition: Epithelial tumors of nasal cavi...

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A Phase 1 Study of SGN-B7H4V in Advanced Solid Tumors

Summary: This study will test the safety of a drug called SGN-B7H4V in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to the body besides treating the disease. Participants will have cancer that has spread in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastat...

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Published Date: May 02, 2022
Published By: Genetic and Rare Diseases Informnation Center

What are the Latest Advances for Adenoid Cystic Carcinoma?
Role of postoperative radiotherapy in resected adenoid cystic carcinoma of the head and neck.
Underwater endoscopic mucosal resection of upper gastrointestinal subepithelial tumors: A case series pilot study (with video).
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Prognosis stratification and postoperative radiation therapy utilization in adenoid cystic carcinoma of the breast.