Simultaneous Integrated Boost (SIB) Planning Approach in Carbon Ion Radiotherapy for Head and Neck Adenoid Cystic Carcinoma
The investigators aim at investigating in a prospective clinical trial whether using a Simoultaneous Integrated Boost of carbon ions treatment planning approach, improving the tumor dose conformation while lowering the unintended dose to the low-risk volume, can significantly reduce the probability of toxicity without affecting Local Control.
• Histologically-proven primary head and neck ACC;
• Unresectable stage or residual macroscopic disease after surgery or multiple microscopic margins after surgery;
• Patient with resectable tumor but refusing surgery
• cN0/pN0 - cN1/pN1 patients (only ipsilateral neck levels I and II)
• Absence of distant metastases or oligometastatic status (patients with ≤ 3 metastatic lung or bone lesions, excluding other sites;
• No previous radiotherapy in head and neck region;
• Karnofsky Performance Status ≥ 70;
• Age ≥ 18 years;
• Written informed consent
• Patients' ability to understand the characteristics and consequences of the clinical trial.