What is the definition of Adenomyosis?

Adenomyosis is a thickening of the walls of the uterus. It occurs when endometrial tissue grows into the outer muscular walls of the uterus. Endometrial tissue forms the lining of the uterus.

What are the alternative names for Adenomyosis?

Endometriosis interna; Adenomyoma; Pelvic pain - adenomyosis

What are the causes for Adenomyosis?

The cause is not known. Sometimes, adenomyosis may cause the uterus to grow in size.

The disease most often occurs in women ages 35 to 50 who have had at least one pregnancy.

What are the symptoms for Adenomyosis?

In many cases, there are no symptoms. When symptoms occur, they can include:

  • Long-term or heavy menstrual bleeding
  • Painful menstrual periods, which gets worse
  • Pelvic pain during intercourse

What are the current treatments for Adenomyosis?

Most women have some adenomyosis as they get close to menopause. However, only a few will have symptoms. Most women do not need treatment.

Birth control pills and an IUD that has progesterone can help decrease heavy bleeding. Medicines such as ibuprofen or naproxen can also help manage symptoms.

Surgery to remove the uterus (hysterectomy) may be done in women with severe symptoms.

What is the outlook (prognosis) for Adenomyosis?

Symptoms most often go away after menopause. Surgery to remove the uterus often gets you rid of symptoms completely.

When should I contact a medical professional for Adenomyosis?

Call your provider if you develop symptoms of adenomyosis.


Brown D, Levine D. The uterus. In: Rumack CM, Levine D, eds. Diagnostic ultrasound. 5th ed. Philadelphia, PA: Elsevier; 2018:chap 15.

Bulun SE. Physiology and pathology of the female reproductive axis. In: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. Williams Textbook of Endocrinology. 14th ed. Philadelphia, PA: Elsevier; 2020:chap 17.

Dolan MS, Hill C, Valea FA. Benign gynecologic lesions: vulva, vagina, cervix, uterus, oviduct, ovary, ultrasound imaging of pelvic structures. In: Lobo RA, Gershenson DM, Lentz GM, Valea FA, eds. Comprehensive Gynecology. 7th ed. Philadelphia, PA: Elsevier; 2017:chap 18.

Gambone JC. Endometriosis and adenomyosis. In: Hacker NF, Gambone JC, Hobel CJ, eds. Hacker & Moore's Essentials of Obstetrics and Gynecology. 6th ed. Philadelphia, PA: Elsevier; 2016:chap 25.

Pietro Santulli
Paris, FR
Mathilde Bourdon
Paris, FR
Xishi F. Liu
Shanghai, CN
Caterina Exacoustos
Rome, IT
Giuseppe Benagiano
Giuseppe Benagiano
Rome, IT
Ivo A. Brosens
Ivo A. Brosens
Leuven, VLG, BE
  • Condition: Chronic Pelvic Pain
  • Journal: Current pain and headache reports
  • Treatment Used: Superior Hypogastric Block
  • Number of Patients: NULL
  • Published —
The study researched the outcomes of superior hypogastric block for chronic pelvic pain.
  • Condition: Adenomyosis
  • Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
  • Treatment Used: High-Intensity Focused Ultrasound
  • Number of Patients: 2311
  • Published —
The study researched the outcomes of using high-intensity focused ultrasound to manage adenomyosis.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: Phase 3
  • Intervention Type: Drug
  • Participants: 674
  • Start Date: June 2021
Phase III Trial to Assess Impact of Ultra-long Versus Long Down-regulation Protocol on IVF/ICSI Outcomes in Infertile Women Presenting With Adenomyosis.
Clinical Trial
  • Status: Not yet recruiting
  • Phase: N/A
  • Intervention Type: Drug
  • Participants: 50
  • Start Date: June 1, 2021
Comparison of E/P Therapy in Continuous Regimen Versus Combination of LNG-IUS Plus E/P