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Condition

Adolescent Idiopathic Scoliosis

Symptoms, Doctors, Treatments, Research & More

Condition 101

What is the definition of Adolescent Idiopathic Scoliosis?

Adolescent idiopathic scoliosis is an abnormal curvature of the spine that appears in late childhood or adolescence. Instead of growing straight, the spine develops a side-to-side curvature, usually in an elongated "s" or "C" shape, and the bones of the spine become slightly twisted or rotated. In m ...

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What are the alternative names for Adolescent Idiopathic Scoliosis?

  • Idiopathic adolescent scoliosis

What are the causes for Adolescent Idiopathic Scoliosis?

The term "idiopathic" means that the cause of this condition is unknown. Adolescent idiopathic scoliosis probably results from a combination of genetic and environmental factors. Studies suggest that the abnormal spinal curvature may be related to hormonal problems, abnormal bone or muscle growth, nervous system abnormalities, or other factors that have not yet been identified.

Researchers suspect that many genes are involved in adolescent idiopathic scoliosis. Some of these genes likely contribute to causing the disorder, while others play a role in determining the severity of spinal curvature and whether the curve is stable or progressive. Although many genes have been studied, few clear and consistent genetic associations with this condition have been identified.

What are the symptoms for Adolescent Idiopathic Scoliosis?

Adolescent idiopathic scoliosis is characterized by an abnormal curvature of the spine (usually in an elongated "S" or "C" shape), along with twisted or rotated bones of the spine. Mild scoliosis generally does not cause pain, problems with movement, or difficulty breathing. It may only be diagnosed if it is noticed during a regular physical examination or a scoliosis screening at school. The most common signs of the condition include a tilt or unevenness (asymmetry) in the shoulders, hips, or waist, or having one leg that appears longer than the other. A small percentage of affected children develop more severe, pronounced spinal curvature.

Scoliosis can occur as a feature of other conditions, including a variety of genetic syndromes. However, adolescent idiopathic scoliosis typically occurs by itself, without signs and symptoms affecting other parts of the body.

What are the current treatments for Adolescent Idiopathic Scoliosis?

Treatment of adolescent idiopathic scoliosis may involve observation, bracing and/or surgery. Treatment recommendations are generally dependent upon the risk of curve progression. Curves progress most during the rapid growth period of the patient (adolescent or pre-adolescent growth spurt). The potential for growth is evaluated by taking into consideration the patient's age, the status of whether females have had their first menstrual period, and radiographic parameters (x-ray studies).

Detailed information about these treatment options can be accessed through the Scoliosis Research Society.

Is Adolescent Idiopathic Scoliosis an inherited disorder?

Adolescent idiopathic scoliosis can be sporadic, which means it occurs in people without a family history of the condition, or it can cluster in families. The inheritance pattern of adolescent idiopathic scoliosis is unclear because many genetic and environmental factors appear to be involved. We do know, however, that having a close relative (such as a parent or sibling) with the condition increases a child's risk of developing it.

Latest Research

Latest Advance
Study
  • Condition: Adolescent Idiopathic Scoliosis (AIS)
  • Journal: Spine deformity
  • Treatment Used: Vertebral Body Stapling (VBS)
  • Number of Patients: 10
  • Published —
This study identified the effectiveness of vertebral body stapling (VBS) in children with idiopathic scoliosis.
Latest Advance
Study
  • Condition: Adolescent Idiopathic Scoliosis
  • Journal: Spine deformity
  • Treatment Used: Bone Remodeling and Disc Morphology in the Distal Unfused Spine After Spinal Fusion
  • Number of Patients: 58
  • Published —
The study researched the outcomes of bone remodeling and disc morphology in the distal unfused spine after spinal fusion for adolescent idiopathic scoliosis.

Clinical Trials

Clinical Trial
Other
  • Status: Not yet recruiting
  • Study Type: Other
  • Participants: 20
  • Start Date: January 2021
Design of a Dynamic Pressure Monitoring System for Orthotic Treatment of Scoliosis
Clinical Trial
Drug
  • Status: Recruiting
  • Study Type: Drug
  • Participants: 90
  • Start Date: September 3, 2020
Dysport ® (abobotulinumtoxinA) as an Adjunctive Treatment to Bracing in the Management of Adolescent Idiopathic Scoliosis