Learn About Adrenocortical Carcinoma

What is the definition of Adrenocortical Carcinoma?

Adrenocortical carcinoma (ACC) is a cancer of the adrenal glands. The adrenal glands are two triangle-shaped glands. One gland is located on top of each kidney.

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What are the alternative names for Adrenocortical Carcinoma?

Tumor - adrenal; ACC - adrenal

What are the causes of Adrenocortical Carcinoma?

ACC is most common in children younger than 5 years old and adults in their 40s and 50s.

The condition may be linked to a cancer syndrome that is passed down through families (inherited). Both men and women can develop this tumor.

ACC can produce the hormones cortisol, aldosterone, estrogen, or testosterone, as well as other hormones. In women the tumor often releases these hormones, which can lead to male characteristics.

ACC is very rare. The cause is unknown.

What are the symptoms of Adrenocortical Carcinoma?

Symptoms of increased cortisol or other adrenal gland hormones may include:

  • Fatty, rounded hump high on the back just below the neck (buffalo hump)
  • Flushed, rounded face with pudgy cheeks (moon face)
  • Obesity
  • Stunted growth (short stature)
  • Virilization -- the appearance of male characteristics, including increased body hair (especially on the face), pubic hair, acne, deepening of the voice, and enlarged clitoris (females)

Symptoms of increased aldosterone are the same as symptoms of low potassium, and include:

  • Muscle cramps
  • Weakness
  • Pain in the abdomen
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What are the current treatments for Adrenocortical Carcinoma?

Primary treatment is surgery to remove the tumor. ACC may not improve with chemotherapy. Medicines may be given to reduce production of cortisol, which causes many of the symptoms.

Who are the top Adrenocortical Carcinoma Local Doctors?
Elite
Highly rated in
21
conditions

German Society For Endocrinology

DE 

Martin Fassnacht is in Germany. Fassnacht is rated as an Elite expert by MediFind in the treatment of Adrenocortical Carcinoma. He is also highly rated in 21 other conditions, according to our data. His top areas of expertise are Adrenocortical Carcinoma, Adrenal Cancer, Adrenal Gland Adenoma, and Pheochromocytoma.

Elite
Highly rated in
25
conditions
Endocrinology

University of Texas System

Physicians Referral Service

1515 Holcombe Blvd 
Houston, TX 77030

Mouhammed Habra is an Endocrinologist in Houston, Texas. Dr. Habra has been practicing medicine for over 27 years and is rated as an Elite doctor by MediFind in the treatment of Adrenocortical Carcinoma. He is also highly rated in 25 other conditions, according to our data. His top areas of expertise are Adrenocortical Carcinoma, Adrenal Cancer, Medullary Thyroid Carcinoma, and Cushing Syndrome. He is licensed to treat patients in Texas. Dr. Habra is currently accepting new patients.

 
 
 
 
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Elite
Highly rated in
11
conditions

University Of Würzburg

Wuerzburg, BY, DE 97080

Matthias Kroiss is in Wuerzburg, Germany. Kroiss is rated as an Elite expert by MediFind in the treatment of Adrenocortical Carcinoma. He is also highly rated in 11 other conditions, according to our data. His top areas of expertise are Adrenocortical Carcinoma, Adrenal Cancer, Medullary Thyroid Carcinoma, and Pheochromocytoma.

What is the outlook (prognosis) for Adrenocortical Carcinoma?

The outcome depends on how early the diagnosis is made and whether the tumor has spread (metastasized). Tumors that have spread usually lead to death within 1 to 3 years.

What are the possible complications of Adrenocortical Carcinoma?

The tumor can spread to the liver, bone, lung, or other areas.

When should I contact a medical professional for Adrenocortical Carcinoma?

Call your provider if you or your child has symptoms of ACC, Cushing syndrome, or failure to grow.

Endocrine glands
Adrenal metastases - CT scan
Adrenal Tumor - CT
What are the latest Adrenocortical Carcinoma Clinical Trials?
Phase II Study for Combination of Camrelizumab and Apatinib in the Second-line Treatment of Recurrent or Metastatic Adrenocortical Carcinoma
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Investigation of the Tumorigenesis of Adrenal Tumors and Evaluation of New Therapeutic Options - Untersuchungen Zur Tumorgenese Von Nebennierentumoren Und Evaluation Neuer Therapieoptionen
What are the Latest Advances for Adrenocortical Carcinoma?
Phase II study of cabazitaxel as second-third line treatment in patients with metastatic adrenocortical carcinoma.
Functioning metastasis from adrenocortical carcinoma.
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Diagnostic Accuracy of CT Texture Analysis in Adrenal Masses: A Systematic Review.
Who are the sources who wrote this article ?

Published Date : July 28, 2020
Published By : Todd Gersten, MD, Hematology/Oncology, Florida Cancer Specialists & Research Institute, Wellington, FL. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

What are the references for this article ?

Allolio B, Fassnacht M. Adrenocortical carcinoma. In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric. 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 107.

National Cancer Institute website. Adrenocortical carcinoma treatment (Adult) (PDQ) - health professional version. www.cancer.gov/types/adrenocortical/hp/adrenocortical-treatment-pdq. Updated November 13, 2019. Accessed October 14, 2020.